Chronic Kidney Diseases, Urinary Tract Infections
Conditions
Keywords
urinary tract, infection, chronic kidney disease, UTI, CKD
Brief summary
This study aims to investigate the etiology and associated risk factors for UTI in Egyptian chronic kidney disease patients. In addition, to identify the isolated micro-organisms and their sensitivity patterns for better anticipation of treatment regimen.
Detailed description
Chronic kidney disease (CKD) patients are at higher risk of urinary tract infections (UTI), as CKD is a state of chronic inflammation, metabolic disturbance and impaired immunocompetence. Moreover, patient with CKD are usually of advanced age and suffer from other comorbidities such as diabetes, hypertension, obesity, and cardiovascular diseases, which also add to their risk of infection. UTI comprises heterogeneous conditions ranging from mild cystitis, easily treated with oral antibiotics, to life-threatening sepsis and multiple organ failure. There is scarce information about risk factors of recurrence of UTI and infection with multidrug-resistant organisms in the Egyptian population.
Interventions
OTHERPatients with urinary tract infection and chronic kidney disease
The data that will be collected from the electronic patient records at the clinics through a google form will include sociodemographic (age, sex, weight and occupation), comorbidities (e.g., HTN, DM), medications used, renal functions (serum creatinine, and CKD stage calculated by 2021 CKD-EPI creatinine equation), and in case of positive urine culture (type of microorganism and antibiogram).
Sponsors
Alexandria University
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Males and non-pregnant females aged ≥ 18 years old 2. Patients with CKD stages (G1 to G4) 3. Patients diagnosed with UTI due to urine culture
Exclusion criteria
1. Non-CKD patients 2. pregnant females 3. CKD patients on immunosuppressant agents 4. ESRD patients on hemodialysis 5. Patients with structural abnormalities which make them liable to frequent UTI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| prevalence of UTI in CKD patients | records will be retrospectively screened from January 2019 till September 2022 | percentage of UTI in CKD patients |
| isolated microorganisms causing UTI in CKD patients | records will be retrospectively screened from January 2019 till September 2022 | isolated microorganisms in cultures causing UTI in CKD patients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| sensitivity pattern of urine cultures in CKD | records will be retrospectively screened from January 2019 till September 2022 | describe sensitivity pattern of urine cultures in CKD |
Countries
Egypt
Outcome results
None listed