Modeling Organ Motion During Abdominal Imaging in Healthy Volunteers

Study and Modeling of Organ Motion During Abdominal Imaging

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05674851

Enrollment

Registered

2023-01-09

Start date

2023-05-23

Completion date

2023-06-27

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Volunteers

Keywords

Magnetic Resonance Imaging (MRI), Abdominal Cancer, Radiation Therapy Planning

Brief summary

In this study, we plan to systematically analyze the motion of organs and tissues in the abdomen, to understand the physical mechanisms of three-dimensional (3D) motion and interactions of abdominal organs and tissues. This work will allow us to learn how to mathematically model and predict abdominal organ motion.

Detailed description

Specifically, we plan to conduct this study in 3 steps, in an order of increasing complexity, starting with the (intra-fractional) respiratory only motion, then adding intra-fractional GI motility motion, and finally the inter-fractional anatomical variations (adding food intakes and fecal excretion). The research methods described will allow the study team to develop the ability to estimate the motion of both tumor target and critical organs given the patient's MRI, CBCT or x-ray fluoroscopy images on the day of radiation treatment.

Interventions

OTHERMRI

collection of MRI scans for mathematical model development

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* No contraindications for MRI (e.g., unsafe MRI implanted devices, shrapnel, history of metal fragments in eyes, neurostimulators, body habitus, claustrophobia). * May have pre-existing medical conditions provided they are capable of completing the exam and their condition is not expected to affect the physical tissue properties of the organs that will be imaged. * Women of child-bearing potential must verbally confirm lack of pregnancy prior to signing consent

Exclusion criteria

* None

Design outcomes

Primary

Measure	Time frame	Description
abdominal respiratory motion as measured by MRI	baseline	—
gastrointestinal motility motion as measured by MRI	baseline	—
inter-fractional motion as measured by MRI	baseline, up to 6 months	inter-fractional motion is defined as the change in motion of organs and tissues between different image examinations on different days

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026