Critical Illness
Conditions
Keywords
capillary refill time, norepinephrine, epinephrine, argipressin, dobutamine, mean arterial pressure
Brief summary
The goal of this observational study is to learn whether different doses of various vasopressor drugs influence capillary refill time (CRT) value in crtically ill patients. The main questions it aims to answer are: * How do vasopressor drugs determine CRT value * How does mean arterial pressure (MAP) determine CRT value * How often CRT value is normal (\< 3 sec) despite hypotensive MAP (\<65 mmHg) Participants will have the CRT measured over the course of the ICU hospitalization. At the end of the study, multiple linear regression will be performed to verify whether different doses of vasopressor drugs influence CRT value.
Detailed description
The goal of this observational study is to learn whether different doses of various vasopressor drugs influence capillary refill time (CRT) value in critically ill patients. The main questions it aims to answer are: * How does norepinephrine dose influence CRT value * How does epinephrine dose influence CRT value * How does argipressin dose influence CRT value * How does dobutamine dose influence CRT value * How does mean arterial pressure (MAP) determine CRT value * How often CRT value is normal (\< 3 sec) despite hypotensive MAP (\<65 mmHg) Participants will have the CRT measured over the course of the ICU hospitalization. At the end of the study, multiple linear regression will be performed to verify whether different doses of vasopressor drugs influence CRT value. CRT will be a dependent variable. Independent variables will be as follows: age, MAP, norepinephrine dose, epinephrine dose, argipressin dose, dobutamine dose. CRT measurements will be performed in a standarized rigor (light, chronometer, pressure and ambient temperature will be the same in all patients)
Interventions
DIAGNOSTIC_TESTCapillary refill time
CRT will be measured by applying firm pressure to the ventral surface of the index finger distal phalanx with a glass microscope slide. The pressure will be increased until the skin is blank and then maintained for 10 seconds. The time for return of the normal skin color will be registered with a chronometer, and \> 3 seconds is defined as abnormal. Light and ambient temperature will be the same for all individuals.
Sponsors
Medical University of Silesia
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* critical illness requiring vasopressor support * invasive blood pressure monitoring
Exclusion criteria
* finger distal phalanx not available * patient in a room of suboptimal ambient temperature
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of norepinephrine dose on CRT value | Through study completion, an average of 1 year | In a multiple linear regression, it will be verified whether different doses of norepinephrine determine CRT value. |
| Effect of mean arterial pressure on CRT value | Through study completion, an average of 1 year | In a multiple linear regression, it will be verified whether different values of MAP determine CRT value. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect of epinephrine dose on CRT value | Through study completion, an average of 1 year | In a multiple linear regression, it will be verified whether different doses of epinephrine determine CRT value. |
| Effect of argipressin dose on CRT value | Through study completion, an average of 1 year | In a multiple linear regression, it will be verified whether different doses of argipressin determine CRT value. |
| Effect of dobutamine dose on CRT value | Through study completion, an average of 1 year | In a multiple linear regression, it will be verified whether different doses of dobutamine determine CRT value. |
| CRT value in MAP <65 mmHg | Through study completion, an average of 1 year | It will be analyzed whether in hypotensive conditions (MAP \<65 mmHg), CRT values are normal (\< 3 sec) |
Countries
Poland
Contacts
Primary ContactZbigniew Putowski, Dr
Outcome results
None listed