Oxidative Stress
Conditions
Brief summary
The goal of this clinical trial is to test the drinking effect of electolyzed alkaline reduced water (ARW) generated from alkaline ionizer (CGM MWPI-2101) on oxidative stress and fatigue after high-intensity exercise in healthy people. The main question\[s\] it aims to answer are: * \[question 1\] Can pH 9.5 EARW reduce oxidative stress compared to purified water (PW) * \[question 2\] Can pH 9.5 EARW decrease fatigue markers in blood Participants will drink water from the experimental device after high-intensity exercise. Blood sample will be collected before exercise, after highly intensive exercise, and after then 15 min. of drinking water. Researchers will compare EARW group and PW group to see the anti-oxidative and anti-fatigue effects.
Detailed description
This study was designed as a randomized, controlled, crossover, double-blind clinical trial with a single intervention of ARW intake (pH 9.5, 10 mL/kg body weight) after highly intense exercise. The participants were divided into two groups, wherein they consumed either purified water (PW group) or EARW (EARW group). Blood samples were collected before exercise, immediately after exercise, and 15 min after drinking water. For the anti-oxidative effect, ROS, NO, GPx, and MDA levels were measured. For the anti-fatigue effect, latate, lactate dehydrogenase, phosphate and calcium were measured.
Interventions
DEVICEElectrolyzed alkaline reduced water generator
Participants drink water (10 mL/kg body weight) generated from the device after intensive excercise.
Sponsors
Ceragem Inc.
Kyu Jae Lee
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SCREENING
Masking
DOUBLE (Subject, Investigator)
Masking description
double blind (participants, investigator)
Intervention model description
The participants were randomly divided into two groups (n = 12) according to the sequence of random numbers obtained through an online number generator. After the first clinical trial, A wash-out period of one week was applied to prevent carry-over before crossing over, and the second clinical trial was performed.
Eligibility
Sex/Gender
ALL
Age
19 Years to 25 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy male participants aged 19-25 years * physically active with a normal body mass index (BMI) * had not smoked for 3 months or consumed alcohol for more than a week prior to the start of the study.
Exclusion criteria
* any kind of visible or known disease * hypertension, * musculoskeletal injuries in the previous three months, * breathing difficulties, * metabolic diseases, * autoimmune disease, * rash, * urticaria.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| EARW consumption is effective in reducing oxidative stress | 15 minutes | Reactive oxygen species, nitric oxide, glutathione peroxidase, malondialdehyde |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The effects of EARW consumption on exercise-induced fatigue markers in healthy young adults | 15 minutes | Lactate levels, phosphate levels, cytokines |
Countries
South Korea
Outcome results
None listed