Renal Dialysis
Conditions
Keywords
Renal Dialysis, Cardiac Function Tests, real-world study, multicenter, prospective, non-randomized, controlled
Brief summary
This study is intended to be a multicenter, prospective, non-randomized, controlled real-world study. Patients receiving L-carnitine injection were included in the experimental group and the control group according to whether they received L-carnitine injection. Patients receiving L-carnitine injection were included in the experimental group, and those receiving L-carnitine injection were included in the control group.To observe the effects of L-carnitine on cardiac function in hemodialysis patients.
Interventions
The patients in the test group were injected with 1-2g (10-20mg/kg) levocarnitine on each dialysis day
Sponsors
The First Affiliated Hospital of Zhejiang Chinese Medical University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Maintenance hemodialysis patients; * 18 years\<80 years; * Have clear consciousness and independent behavior ability; * Before dialysis, the total carnitine concentration was less than 40 umol/L, or the free carnitine concentration was less than 35 umol/L.
Exclusion criteria
* Acute cardiovascular and cerebrovascular diseases occurred within 1 month; * Infectious diseases occurred within 1 month; Treatment with glucocorticoid or immunosuppressant; * Patients who have used L-carnitine within 2 weeks. * Hematological system tumor or tumor;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in Left ventricular ejection fraction | baseline and week 12 |
Secondary
| Measure | Time frame |
|---|---|
| Change from baseline in left ventricular short axis shortening rate | baseline and week 12 |
| Change from baseline in stroke volume | baseline and week 12 |
| Change from baseline in the ratio of peak E to peak A of mitral valve blood flow velocity in early and late diastolic periods | baseline and week 12 |
| Change from baseline in Brain natriuretic peptide level | baseline ,week 4 and week 12 |
| Change from baseline in upper arm circumference | baseline and week 12 |
| Change from baseline in prealbumin | baseline and week 12 |
| Change from baseline in hemoglobin | baseline and week 12 |
| Change from baseline in serum albumin | baseline and week 12 |
Countries
China
Outcome results
None listed