Infection, Hospital
Conditions
Keywords
Infection Control, Infections, Intensive Care Units, Pneumonia, Ventilator Associated, Catheter-Related Infections, Urinary Tract Infections, Organosilanes, Costs and Cost Analyses
Brief summary
The purpose of this study is to evaluate if surface disinfection with organosilane associated with traditional cleaning reduces the incidence of healthcare-associated infections (HAIs) in intensive care units when compared with traditional cleaning alone.
Interventions
OTHERSurface disinfection with Organosilane
Organosilane will be sprayed on the surfaces, using an atomizer. When the environment has been completely covered (i.e., when all surfaces and equipment have a slightly damp film), we will proceed with the second phase of the disinfection of all heavily touched surfaces. surfaces of the bed, with a microfiber cloth with organosilane.
Sponsors
Hospital Sirio-Libanes
Hospital Moinhos de Vento
Hospital Alemão Oswaldo Cruz
Hospital do Coracao
Beneficência Portuguesa de São Paulo
Hospital Israelita Albert Einstein
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
Randomized, controlled, cluster, crossover, trial
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients aged 18 years and older who will be admitted to the participating ICUs
Exclusion criteria
* Patients under 18 years * ICUs that may use any organosilane formulation for surface disinfection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of healthcare associated infections | 6 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Contamination of environmental surfaces by multi-resistant microorganisms | 6 months | We will collect environmental samples from 4 surfaces highly touched by the patient, health team and family (bed rails, monitor and infusion pump buttons, meal table or procedure table, and IV drip stand) before and after the intervention. (end of the 6 months). For analysis of the environmental samples, characterization of the density and microbiological profile of biofilms on the different surfaces of the ICU beds will be performed using large-scale DNA sequencing techniques associated with bioinformatics analysis. |
| Incidence of ventilator-associated pneumonia | 6 months | — |
| Incidence of central line-associated blood stream infections | 6 months | — |
| Incidence of catheter-associated urinary tract infection | 6 months | — |
| Intensive care unit length of stay costs | 6 months | — |
Countries
Brazil
Outcome results
None listed