Heart Failure
Conditions
Brief summary
The goal of this observational study is to learn about heart function and high lung blood pressure in patients with heart failure. The main question\[s\] it aims to answer are whether we can improve the ability to predict patients who will have complications after they receive treatment including heart transplant and left ventricular assist devices.
Detailed description
Prospective cohort study of patients with heart failure with reduced ejection fraction that are referred for diagnostic right heart catheterization as part of their evaluation for candidacy for advanced heart failure therapies.
Interventions
DIAGNOSTIC_TESTRight Heart Catheterization
Procedure
Sponsors
Heart and Stroke Foundation of Canada
Mount Sinai Hospital, Canada
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Adults age 18 years or older * Heart failure with reduced ejection fraction (\<40%) * referred for RHC at our centre for evaluation of candidacy for advanced HF therapies.
Exclusion criteria
Severe valvular or complex congenital heart disease Short-term mechanical circulatory support for progressive cardiogenic shock (e.g. extracorporeal membrane oxygenation) Acute coronary syndrome or revascularization occurred within 7 days prior to the RHC. Pregnant or breast-feeding Known hypersensitivity to sodium nitroprusside Advanced liver dysfunction Reduced capacity or inability to provide informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean pulmonary artery pressure | First study 1 day visit | Hemodynamic measurement |
| right ventricular end systolic elastance | First study 1 day visit | Hemodynamic measurement |
| pulmonary arterial elastance | First study 1 day visit | hemodynamic measurement |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Right ventricular failure after heart transplant | 1 year | Clinical outcome |
| Right ventricular failure after left ventricular assist device | 1 year | Clinical outcome |
Other
| Measure | Time frame | Description |
|---|---|---|
| right ventricular pulmonary arterial elastance coupling response to vasodilator | First study 1 day visit | Hemodynamic measurement |
Countries
Canada
Contacts
Primary ContactSusanna Mak, MD PhD
Outcome results
None listed