Ischemic Heart Disease
Conditions
Brief summary
The goal of this observational study is to test the feasibility of intracoronary adenosine administration during coronary flow reserve(CFR) and index of microcirculatory resistance(IMR) assessment in a population with angina. The main questions it aims to answer are: * Repeatability of CFR and IMR assessment while hyperemia with intracoronary adenosine was administered. * Evaluate the correlation of the intrinsic signal of coronary waveform versus physiologic ischemia, while defined by fractional flow reserve(FFR) and CFR respectively. * The predictive value of FFR, CFR, and IMR on major adverse cardiovascular outcomes in 3 years Participants will undergo FFR, CFR, and IMR assessments in the catheterization laboratory of the National Taiwan University Hospital Hsin-Chu Branch, then clinical events follow up for 3 years.
Interventions
PROCEDURECFR and IMR group
Participants will undergo repeat intracoronary adenosine administration during CFR and IMR measurement
Sponsors
National Taiwan University Hospital Hsin-Chu Branch
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Participants with angina
Exclusion criteria
* Severe valvular heart disease * History of asthma * Heart rate less than 50 beats per minute * systolic blood pressure less than 90 mmHg
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Repeatability of CFR and IMR value | 10 minutes | To compare the difference of individual value, while repeat the measurement within 1 minutes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Major adverse cardiovascular outcomes | 3 year | Including death, myocardial infarction, stroke and heart failure |
Countries
Taiwan
Contacts
Primary ContactChien-Boon Jong, MD
Outcome results
None listed