Glioma
Conditions
Brief summary
The 18-kDa translocator protein (TSPO) is a mitochondrial protein that is weakly expressed in the healthy brain. However, there is an increase in the expression of TSPO in glial tumors. It is even associated with a higher malignancy and a shorter survival of patients. Among the different TSPO ligands, the most commonly used tracers in PET imaging are \[18F\]DPA-714 and 18F-GE180. We hypothesize that \[18F\]DPA-714 PET could improve the current performance for tumor grade definition in vivo, which is a major issue for the therapeutic management of gliomas.
Interventions
DRUG[18F]DPA-714
Participant received one injection of 200 MBq of \[18F\]DPA-714
Sponsors
Center Eugene Marquis
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age greater than or equal to 18 years * Suspicion of an operable diffuse glioma * Written informed consent (signed) * Affiliated or beneficiary of a social security plan
Exclusion criteria
* Suspicion of grade I glioma * Surgical urgency (less than 8 days between the suspected diagnosis and surgery) * Pregnant or breastfeeding woman * Persons deprived of liberty or under guardianship * Impossibility to undergo the medical follow-up of the trial for geographical, social or psychological reasons
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic performances of [18F]DPA-714 PET for glioma grading obtained by stereotactic biopsies of glioma | [18F]DPA-714 PET performed up to 30 days before brain surgery | Sensitivity and specificity of \[18F\]DPA-714 PET using anatomopathological assessment of biopsies as gold standard |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of [18F]DPA-714 PET quantitative parameters with anatomopathological assessment of the surgery specimen | [18F]DPA-714 PET performed up to 30 days before brain surgery | Comparison of \[18F\]DPA-714 PET quantitative parameters with the histological types of gliomas, with the IDH1-mutational status, and the 1p19q codeletion status |
| Comparison of [18F]DPA-714 PET quantitative parameters with tumor microenvironment | [18F]DPA-714 PET performed up to 30 days before brain surgery | Comparison of \[18F\]DPA-714 PET quantitative parameters with the frequency and phenotype of tumor microenvironment different glioma-associated cells |
Outcome results
None listed