Stroke, Sarcopenia
Conditions
Brief summary
Primary research purpose: -Prospective study to screen post stroke patients with sarcopenia and evaluate its effect on recovery Secondary research purpose: * To determine the degree of sarcopenia and correlation with poor functional prognosis of stroke in the stroke patient group. * To determine the degree of sarcopenia and correlation with dixon MRI of thigh muscle * To evaluate surface EMG (SEMG)-based signals and correlation with sarcopenia * To determine the degree of sarcopenia and correlation with brain morphometric changes
Detailed description
Patients with first-ever stroke will be enrolled and assessed for sarcopenia. The evaluation parameters will include standard sarcopenia parameters and also SEMG-based signals and imaging studies.
Interventions
DIAGNOSTIC_TESTDEXA Scan
Fu of diagnostic tests
Sponsors
Saint Vincent's Hospital, Korea
The Catholic University of Korea
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients 65 years of age or older, stroke patients with first onset within 4 weeks
Exclusion criteria
* Patients who have not been evaluated for sarcopenia * Patients with neuromuscular diseases other than stroke that may affect gait function * Patients unable to conduct clinical trials according to instructions * Patients with uncontrolled medical/surgical disease * Patients with metal substances in the body such as cardiac pacemakers, cochlear implants, etc. * Patients who have difficulty collecting blood * Patients who are difficult to follow up after 6 months of onset due to moving to another area * Patients who have Parkinson's disease, dementia, or have a history of neuromuscular diseases such as Guillain-Barré syndrome or myasthenia gravis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of Modified Rankin Scale | 6 months from the first onset of the stroke | Functional Disability -\> The scale runs from 0-6, running from perfect health without symptoms(0) to death(6). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| quadriceps muscle strength | within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke | Lower extremity strength assessment:change in isometric quadriceps muscle strength (kg) from initial evaluation to the final evaluation |
| Fugl-Meyer motor scale | within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke | Motor function assessment : Fugl-Meyer motor scale from initial evaluation to the final evaluation (Upper Extremity maximum score = 66; Lower Extremity maximum score = 34, Higher score means better outcome) |
| Functional Ambulation Category | within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke | Gait function assessment : Functional Ambulation Category from initial evaluation to the final evaluation (Minimum 0, Maximum 5; Higher score means better outcome) |
| Berg balance scale | within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke | Balance function: change in Berg balance scale from initial evaluation to the final evaluation (Minimum score 0, Maximum score 56, Higher score means better outcome) |
| Hand grip strength | within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke | Grip strength: Grip strength will be measured using a dynamometer |
| Thigh Dixon MRI | within 4 weeks and 6 months from the first onset of the stroke | Muscle quality : muscle circumference measured by the thigh MRI from initial evaluation to the final evaluation |
| Muscle ultrasonography | within 4 weeks and 6 months from the first onset of the stroke | muscle thickness(cm) measured by the ultrasound of the quadriceps muscle from initial evaluation to the final evaluation |
| serum biomarkers for sarcopenia | within 4 weeks from the first onset of the stroke | BNDF, IL-6 |
| Digitalized SEMG signals | within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke | state of the art EMG signals will be collected to assess muscle quality changes after stroke |
| Brain MRI | within 4 weeks and 6 months from the first onset of the stroke | Brain atrophy : change in the Global cortical atrophy scale(0-3) of the cerebral cortex from initial evaluation to the final evaluation |
Countries
South Korea
Outcome results
None listed