EMOTION & COGNITION IN MYOCLONUS DYSTONIA (AGENT10-ECODYST)

CEREBELLAR INVOLVEMENT IN MOTOR, COGNITIVE AND EMOTIONAL PROCESSES IN MYOCLONUS DYSTONIA

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05671068

Enrollment

Registered

2023-01-04

Start date

2023-01-20

Completion date

2024-02-19

Last updated

2026-01-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

DYT11, Myoclonus-Dystonia

Brief summary

Background: Myoclonus dystonia (DYT-SGCE) is characterized by myoclonus and dystonia. Such condition is associated with a high prevalence of psychiatric symptoms which are part of the phenotype. The mechanisms underlying these non-motor symptoms are still poorly understood. Objective: To investigate the neural correlates of cognition and emotion in DYT-SGCE. Design: Participants will have 1 - 2 visits at the clinical center. The total participation time is less than 24 hours. Participants will have a medical interview and a neurological exam. They may give a urine sample before MRI. Participants will have a short neuropsychologic and psychiatric interviews. Participants will have MRI scans. They will do small tasks or be asked to imagine things during the scanning.

Detailed description

Eligibility: DYT-SGCE patients and healthy volunteers (HV) between 15 and 60 years old.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

15 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

For all participants: * Age between 15-60 years * Able to give informed consent. For patients: * An established diagnostic of DYT-SGCE * No change in medication (related to DYT-SGCE) for a month For controls: * No neurological symptoms * No medication except oral contraception

Exclusion criteria

* No deprivation of liberty * Inability to give a consent * Established cognitive alteration * Contraindication to MRI (per MRI safety checklist) * Severe chronic psychiatric illness

Design outcomes

Primary

Measure	Time frame	Description
BOLD signal derived from the functional magnetic resonance imaging	46 month	Explore the differences in DYT-SGCE compared to HV

Countries

France

Contacts

PRINCIPAL_INVESTIGATOREmmanuel Roze, Md, PhD

Department of neurology, Pitié-Salpêtrière Hospital, Paris

Outcome results