Prognostic Significance of Lymph Node Ratio in Rectal Cancer on Overall Survival

Prognostic Significance of Lymph Node Ratio in Rectal Cancer on Overall Survival: An Alternative Not a Substitute

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05667259

Enrollment

229

Registered

2022-12-28

Start date

2012-01-01

Completion date

2022-12-01

Last updated

2022-12-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer, Rectum

Keywords

Cancer Rectum, Lymph node ratio, Overall Survival, Prognosis

Brief summary

This study was conducted to compare the significance of lymph node ratio and absolute count of positive lymph node count on overall survival in patients with rectal cancer who underwent resection with curative intent

Detailed description

Retrospective cohort study carried on 229 patients with non-metastatic rectal cancer, admitted in tertiary hospitals along 10 years, between 2012 to 2022, and underwent radical resection surgery with curative intent. Exclusion criteria included patients with familial adenomatous polyposis, multiple synchronous or metachronous rectal cancers, early post-operative recurrence or death within 3 months. Demographic, histopathological, follow up and outcome data were collected. Demographics included age, gender, family history, and chief complaint at presentation. Histopathological data included tumor site, grade, vascular-perineural invasion, total number of lymph nodes removed, and positive lymph nodes. Lymph node ratio was defined as the ratio of positive lymph nodes to the total number of retrieved lymph nodes in histopathology specimen. Survival was calculated for each patient based on time of surgery to time of death Statistical analysis will be used to evaluate the effect of lymph node ratio on overall survival.

Interventions

OTHERSurgical resection for cancer rectum

Curative resection for cancer recum

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

19 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Patient with rectal cancer of stage I-III. * patients underwent radical resection with curative intent.

Exclusion criteria

* Patients with Familial Adenomatous Polyposis, multiple synchronous or metachronous rectal cancers. * Early post-operative recurrence, or death within 3 months.

Design outcomes

Primary

Measure	Time frame	Description
Overall Survival	up to 10 years (From date of surgery to the date date of death)	Survival was calculated for each patient based on time of surgery to time of death.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026