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Examining Changes in Muscle Size and Body Composition Between Two Hypertrophy Resistance Training Programs in Males

A Pilot Study Examining Differences in Waist, Upper-arm, Mid-thigh Circumference and Body Composition When Training to Momentary Muscular Fatigue Versus Close Failure-proximity Amongst Healthy Male Biological Sex University-aged Students

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05667233
Enrollment
13
Registered
2022-12-28
Start date
2023-02-06
Completion date
2023-04-03
Last updated
2023-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Body Weight Changes, Hypertrophy, Muscle Size

Keywords

Exercise, Resistance Training

Brief summary

This study aims to investigate if a less physically and psychologically taxing approach to resistance training can generate equal or greater outcomes when compared to a more physically and psychologically taxing approach.

Detailed description

Resistance training is commonly used to improve body composition, gain strength, increase muscle size (i.e., hypertrophy) and prevent muscle atrophy (i.e., muscle wasting). The most optimal mode of building muscle remains unclear, however there are many mechanisms that can be tested to yield optimal results. One variable that can be manipulated when designing a hypertrophy-focused resistance training regimen is intensity (i.e., proximity-to-failure). Proximity-to-failure is defined as the number of repetitions remaining in a set of prescribed exercises prior to reaching momentary muscular failure (MMF). MMF is when an individual cannot complete the lowering or concentric phase of a given repetition with a full range-of-motion without deviation from the prescribed form of the exercise. For all lifters, particularly amongst older populations, it can be psychologically demanding to push to MMF, and may increase the risk of delayed onset muscle soreness (DOMS) and/or injury due to technical breakdown. In contrast, there is some evidence that suggests training to a slightly less intensity (i.e., within 1-4 repetitions in reserve \[RIR\]) may result in comparable hypertrophic results with less of a physical and psychological demand on participants. For these reasons, this study looks to investigate if an easier (i.e., less intense) approach to training such as training with repetitions in reserve (RIR), warrants similar or better muscle hypertrophy adaptations to MMF.

Interventions

Participants will undergo a high exertion machine-based resistance training protocol.

Sponsors

Dalhousie University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE

Intervention model description

Participants will be randomly assigned to one of two parallel groups (train to failure OR train to non-failure) and stratified according to their recent training experience (beginner \[3-9 months experience\], intermediate \[9-18 months experience\], advanced \[\>18 months experience\]).

Eligibility

Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* biological male * age 18 years or older * enrolled at Dalhousie university * minimum 3-months of consistent (at least 2x/week) resistance training experience

Exclusion criteria

* body fat percentage 25% or greater (obese) * use of performance enhancing drugs that aim to increase rate of muscle growth (i.e., androgenic steroids, anabolic steroids, selective androgen receptive modulators, growth hormone).

Design outcomes

Primary

MeasureTime frameDescription
Segment girth (cm)8-weeksUpper arm (biceps) circumference, mid-thigh (quadriceps) circumference, waist (abdomen) circumference

Secondary

MeasureTime frameDescription
Body composition (kg)8-weeksFat mass, Fat-free mass, Total Body Mass (fat mass + fat free mass)
Body Fat Percentage8-weeksFat Mass (kg) / Total Body mass (kg) \* 100

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026