Inflammatory Response, Periodontal Inflammation, Periodontitis
Conditions
Brief summary
The study included 70 systemically healthy individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal disease. Blood samples were taken for the examination of DNI, white blood cells (WBC), immature granulocytes (IG), procalcitonin, C-reactive protein (CRP), lymphocyte count and neutrophil count. For the patients with periodontitis, blood sample assays were repeated 3 months after NSPT.
Detailed description
The role of the Delta Neutrophil Index (DNI) in the pathogenesis and follow-up of periodontal disease has not been comprehensively documented. The study included 70 systemically healthy individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal disease. Blood samples were taken for the examination of DNI, white blood cells (WBC), immature granulocytes (IG), procalcitonin, C-reactive protein (CRP), lymphocyte count and neutrophil count. For the patients with periodontitis, blood sample assays were repeated 3 months after NSPT.
Interventions
OTHEROnly routine non-surgical periodontal treatment was applied to the patients.
The study included 70 systemically healthy individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal disease. Blood samples were taken for the examination of DNI, white blood cells (WBC), immature granulocytes (IG), procalcitonin, C-reactive protein (CRP), lymphocyte count and neutrophil count. For the patients with periodontitis, blood sample assays were repeated 3 months after non-surgical periodontal treatment
Sponsors
Kahramanmaras Sutcu Imam University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients diagnosed with periodontitis * Patients have more than 20 teeth in the mouth * Minimum age 18 * Maximum age 65
Exclusion criteria
* Patients with any systemic disease * Active smokers * Pregnant or breastfeeding * Patients have used any antibiotic or anti-inflammatory drug in the last 6 months * Patients have received any periodontal treatment in the last 6 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Delta Neutrophil Index values of periodontal treatment in patients with periodontitis. | 12 weeks | We expect a decrease in the Delta Neutrophil Index values after non-surgical periodontal treatment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neutrophil-lymphocyte ratio (NLR) values after non-surgical periodontal treatment. | 12 weeks | We expect a decrease in the neutrophil-lymphocyte ratio (NLR) values after non-surgical periodontal treatment. |
Countries
Turkey (Türkiye)
Outcome results
None listed