Rectal Cancer
Conditions
Keywords
rectal cancer, concurrent chemoradiotherapy, sarcopenia, multimodal rehabilitation
Brief summary
Investigators use clinical trial to explore the role of sarcopenia and multimodal rehabilitation in prognosis of rectal cancer patients receiving concurrent chemoradiotherapy.
Detailed description
The impact of sarcopenia and the effect of multimodal rehabilitation will be evaluated in the rectal cancer patients receiving pre-operative concurrent chemoradiotherapy. This is a randomized trial.
Interventions
OTHERfor excise, nutrition consultant, nutrition supplement and psychologic intervention.
for excise, nutrition consultant, nutrition supplement and psychologic intervention.
Sponsors
Chang Gung Memorial Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* age\>20 * rectal cancer patients receiving concurrent chemoradiotherapy * agree to join the trial and sign the informed consent form
Exclusion criteria
* unstable vital sign * unable to excise * not suitable after evaluation by Principal Investigator
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sarcopenia assessment with muscle power | baseline | Assessment with Grip strength(Kg) |
| Sarcopenia assessment with speed | baseline | Assessment with speed(m/s) |
| Sarcopenia assessment with DXA | baseline | Assessment with DXA(g/cm2) |
| Sarcopenia assessment with abdominal CT | baseline | Assessment with ASM/heigh2(Kg/m2) of L3 level |
| Nutrition assessment with albuminemia | baseline | albumin level in serum |
| Nutrition assessment with pre-albuminemia | baseline | pre-albumin level in serum |
| Nutrition assessment with PGSGA | baseline | patient-generated subjective global assessment Scale (Total score 0\ 9 ;score 1-3 Good nutritional intake. score 4-8 Moderate malnutrition. score \>9Severe malnutrition) |
| Psychological assessment | baseline | Taiwanese Depression Questionnaire (TDQ)Total score 0-54; score \>8 emotionally stable ;Score 9 \ 14 Pay attention to emotional changes Score 15 \ 18 pressure load reaches the critical point; Score 19-28 It is recommended to find a professional institution or medical unit assistance ;Scores 29 or more must find professional medical units to get involved |
| Harris Benedict Equation | baseline | Total Daily Energy Expenditure |
Countries
Taiwan
Contacts
Primary ContactWan-Hsiang Hu
Outcome results
None listed