Orexin-A Levels in Insomnia Patients

Comparison of Plasma Orexin-A Levels and Awakening Time From Anesthesia in Patients With and Without Insomnia Who Had Laparoscopic Cholecystectomy Under General Anesthesia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05664295

Enrollment

Registered

2022-12-23

Start date

2022-12-30

Completion date

2023-02-10

Last updated

2023-03-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Insomnia

Brief summary

In the pathophysiology of insomnia, the increase of the orexin-A (OXA) peptide released from orexin neurons in the lateral hypothalamus plays an important role. Orexins takes part at the emergence of anesthesia. In the literature, investigators could not attain any studies about the arousal of insomnia patients from anesthesia. In this study, the effect of this peptide on the emergence process from anesthesia was investigated by comparing plasma OXA levels before and after anesthesia in insomnia patients.

Detailed description

ASA (American Society of Anesthesiologists) I-II patients aged 18-65 years who underwent elective laparoscopic cholecystectomy were included in the study. Patients were evaluated with the Jenkins Sleep Disorders scale and Epworth Sleepiness scale during preoperative examination and were divided into insomnia and control groups. Blood samples were obtained for OXA and glucose levels at anesthesia induction, 5 minutes after extubation and 30 minutes after extubation. The times from stopping anesthesia to eyes opening and extubation and end-tidal sevoflurane concentrations at these time points were recorded.

Interventions

DIAGNOSTIC_TESTJenkins Sleep Disorders scale and Epworth Sleepiness scale

Jenkins Sleep Disorders scale and Epworth Sleepiness scale

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* male patients undergo elective laparoscopic cholecystectomy under general anesthesia * Between 18-65 age * ASA I-II

Exclusion criteria

* ASA≥III * Patients with obstructive sleep apnea syndrome * Bleeding over 500 ml * Allergic to anesthetic agents * Patients with a BMI \> 30 kg/m2

Design outcomes

Primary

Measure	Time frame	Description
Orexin-A Levels	at anesthesia induction, 5 minutes after extubation and 30 minutes after extubation	plasma OXA levels anesthesia induction and after anesthesia in insomnia patients

Secondary

Measure	Time frame	Description
recovery time from general anesthesia	time of eyes opening and time of extubation	The relationship between plasma OXA levels and recovery times from anesthesia in insomnia patients

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026