Thrombosis, Thrombus, Brain
Conditions
Keywords
Thrombus, Neuroimaging, High-resolution vessel wall imaging, Cerebral ischemia, Cerebral artery
Brief summary
In the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment.
Detailed description
Cerebral ischemic stroke resulting from thrombosis causes high disability and mortality. There are few biomarkers to evaluate arterial thrombophilia until now. Previous studies have demonstrated that atherosclerotic plaque rupture and erosion are major etiologies initiating thrombosis. Based on previous works targeting the role of plaque and blood flow in cerebrovascular disease, in the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to explore the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment. The study's objective was to solve the challenges in the mechanism of thrombus features and the outcome of recanalization therapy, thus helping improve the primary and secondary prevention of cerebrovascular disease.
Interventions
DIAGNOSTIC_TESTthrombus imaging appearance
Imaging appearance of intracranial and/or extracranial arterial thrombus
Sponsors
Chinese PLA General Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years * Extracranial and/or intracranial artery occlusion confirmed by angiography * Available for magnetic resonance high-resolution vessel wall imaging * Written informed consent obtained
Exclusion criteria
* Extracranial and/or intracranial artery mild to moderate stenosis * Pregnant women * Restenosis or occlusion after artery stenting placement
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of Successful Recanalization | 1-3 Years | Antegrade blood flow through the recanalized portion was assessed by thrombolysis in myocardial infarction (TIMI) score or thrombolysis in cerebral infarction (TICI) score. TIMI≥2 or TICI≥2b was defined as successful recanalization. |
| Ischemic Stroke Occurrence | 1-3 Years | Ischemic stroke occurrence during follow-up period which was confirmed by neuroimaging |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants with Adverse Events | 1-3 Years | hemorrhagic or ischemic stroke after recanalization treatment |
Countries
China
Contacts
Primary ContactJinhao Lyu, M.D.
Outcome results
None listed