Organ Preservation Solution
Conditions
Keywords
machine perfusion, liver transplant, low/mid volume transplant center
Brief summary
Introduction: Machine perfusion (MP) was developed to expand the available donor pool and to improve liver transplantation outcomes. Despite optimal results in clinical trials, MP benefit outside of clinical experimentation in unknown. Low/mid volume centres (L/MVCs) may face logistical/economical difficulties that may in turn hamper optimal MP results. Methods: An Online 22-item survey on the use of machine perfusion for liver transplantation outside of clinical trials, was distributed to worldwide LT centres representatives. Variables of interest included MP logistics, MP technicalities, MP results, post-MP LT results. Responding centres were grouped into high volume centre (HVCs)(defined as \>60 LTs per year in 2019) and L/MVCs. Results from HVCs vs L/MVCs were compared.
Interventions
DEVICEMACHINE PERFUSION
Different outcomes of MP use in low/mid-volume and high-volume LT centres
Sponsors
Roberta Angelico
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Inclusion criteria
* LT centres that use MP * LT centres which perform LT before pandemic time (before 2019 included) * LT centres which perform LT from cadaveric donors and living donors
Exclusion criteria
* LT centres that not use MP * LT centres that use MP but on clinical trials
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Liver transplant(LT) centres different use of graft after utilization of machine perfusion (MP) | 12/2021 - 03/2022 | High Volume Centers and Low/Mid Volume centers differ in their rates of graft utilization after Machine perfusion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Liver Transplant outcomes after Machine Perfusion | 12/2021 - 03/2022 | Reported patient survival rates for Liver Transplant after Machine Perfusion |
Countries
Italy
Outcome results
None listed