Clinical Application of Quantitative Ultrasonographic Analysis in Early Kidney Injury

The Clinical Application of Ultrasound for Acute Kidney Injury During Sepsis - From Macroscopic to Microscopic Renal Perfusion Perspectives

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05662774

Enrollment

100

Registered

2022-12-22

Start date

2023-01-01

Completion date

2024-11-30

Last updated

2022-12-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patient Admitted to Hospital With Acute Kidney Injury Due to Sepsis

Keywords

Acute kidney injury, contrast-enhanced ultrasound, renal perfusion, microcirculation

Brief summary

The purpose of this study was to quantify overall blood flow and renal cortical perfusion in patients with septic acute kidney injury (AKI) using ultrasound (US) Doppler and contrast-enhanced ultrasound (CEUS).

Detailed description

Kidney ultrasound is the most widely used imaging modality in initial AKI workup as it is widely available and free of complications. It is clinically feasible to use US Doppler and contrast-enhanced US (CEUS) to detect macroscopic and microscopic changes in renal blood flow, and also cardiac output alterations.The aim was to analyze changes in US Doppler and CEUS quantitative parameters in patients with septic AKI to explore perfusion within the renal parenchyma, and also measure global renal blood flow and cardiac output.

Interventions

DIAGNOSTIC_TESTUltrasound contrast agent (Sonovue)

Patients are diagnosed by intravenous injection of ultrasound contrast on the first day of admission and information is collected by diagnostic ultrasound instruments

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

19 Years to 90 Years

Healthy volunteers

Inclusion criteria

1. Meets the AKI diagnostic criteria of the Kidney Disease: Improving Global Outcomes (KDIGO) 2. Meets Sepsis 3.0 diagnostic criteria for sepsis: infection + SOFA ≥ 2

Exclusion criteria

1. Urinary tract obstruction, hydronephrosis, etc. 2. Left ventricular ejection fraction \<30% (measured by transthoracic echocardiography), systolic pulmonary artery pressure \>90 mmHg (measured by transthoracic echocardiography) 3. Allergy or adverse reaction to contrast media

Design outcomes

Primary

Measure	Time frame	Description
Ultrasound Doppler parameters	First 24 hours after admission	Time-averaged velocity (TAV)in cm/s
Ultrasonography parameters	First 24 hours after admission	Time to peak (TTP)in senconds

Countries

China

Contacts

Primary ContactPeiqing Liu

liupeiqing8877@163.com+8618625268629

Backup ContactYunzhu YU

+8613382147113

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026