Effect of General Anesthesia Method on Cardiac Risk Patients on Ischemia Modified Markers

Effect of General Anesthesia Method Chosen in Non-cardiac Surgery of Cardiac Risk Patients on Ischemia Modified Albumin and Heart-Type Fatty Acid-Binding Protein (H-FABP) Levels

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05662163

Enrollment

Registered

2022-12-22

Start date

2022-12-30

Completion date

2023-12-30

Last updated

2022-12-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Brief summary

To examine the effects of the general anesthesia method chosen in non-cardiac surgical operations of patients with cardiac risk on the levels of cardiac markers

Detailed description

To examine the effects of the general anesthesia method chosen in non-cardiac surgical operations of patients with cardiac risk on the levels of cardiac markers like; serum levels of the Creatine Kinase, Creatine Kinase Myocardial Band, high sensitive troponin, heart-type fatty acid-binding protein, ischemia-modified albumin and albumin. And evaluate the effect of anesthesia method on haemodynamic.

Interventions

PROCEDURETIVA

Anesthesia will be maintained with propofol (6-10 mg/kg/hour) and remifentanil (0.1-0.3 μg/kg/min).

PROCEDUREGENERAL ANESTHESIA

Anesthesia will be maintained with sevoflurane (2 ml/min) 50% oxygen and remifentanil (0.1-0.3 μg/kg/min).

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

* Being 18 years or older * Getting a score of 2 and above according to the Lee cardiac index * Having a non-cardiac surgical procedure that will take at least three hours * ASA II or III

Exclusion criteria

* Under 18 years old * Those who refused to participate in the study * Patients with chronic renal failure * Patients with creatinine value ≥ 1.5 mg/dl * Surgery that takes less than 3 hours * Patients with liver failure * Refusing to participate in the study * Being allergic to the drugs used

Design outcomes

Primary

Measure	Time frame	Description
comparing serum levels of ischemia modified albumin	intraoperative period	serum levels of ischemia modified albumin (in terms of IU/ML)
comparing serum levels of heart fatty acid binding protein	intraoperative period	serum levels of heart fatty acid binding protein (in terms of mcg/L)

Secondary

Measure	Time frame	Description
The effect of anesthesia method used in cardiac risk patients in terms of ephedrine consumption	intraoperative period	used ephedrine amount (mg)

Contacts

Primary ContactAyşenur Dostbil

adostbil@hotmail.com+905333677796

Backup ContactCanan Atalay

cananatalay@hotmail.com+905333635318

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026