Congenital Cardiomyopathy, Neurodevelopmental Disorders
Conditions
Keywords
EEG, Neurodevelopmental Disorders, Congenital Cardiomyopathy, Orality Disorders
Brief summary
Congenital cardiopathy are frequent malformations (1/100 birth). The progress of surgery permit a survival rate at the adult age of more than 90%. The long terms consequences must be taken in account and the nerodevelopmental disorders are in first place (intelectual deficiency, autism spectrum disorders, or attention disorders) and presents in 30 to 60% of the patients (Calmant, 2015). The impact can be important on the scolarity, the studies, the professional activity and finaly on the quality of life of the patients becomming adults. The identification of the risk factors on surgery period should permit to propose the most adapted follow-up to the specifics needs of each patients. On the scientific plans, the identification of early markers on brain dammage on EEG should permit to better apprehend the physiopathologic mecanisms involved.
Detailed description
Interest of early EEG on congenital cardiopathy surgery to predict the neurodevelopmental disorders occurence. Congenital cardiopathy are frequent malformations (1/100 birth). The progress of surgery permit a survival rate at the adult age of more than 90%. The long terms consequences must be taken in account and the nerodevelopmental disorders are in first place (intelectual deficiency, autism spectrum disorders, or attention disorders) and presents in 30 to 60% of the patients (Calmant, 2015). The impact can be important on the scolarity, the studies, the professional activity and finaly on the quality of life of the patients becomming adults. The identification of the risk factors on surgery period should permit to propose the most adapted follow-up to the specifics needs of each patients. On the scientific plans, the identification of early markers on brain dammage on EEG should permit to better apprehend the physiopathologic mecanisms involved.
Interventions
None listed
Sponsors
University Hospital, Lille
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 1 Years
Healthy volunteers
No
Inclusion criteria
* Child of less than 1 year admitted for cardiac surgery on extracorporal circulation on the CHU of Lille during the study period. * Child with congenital cardiopathy with necessity to be operated before 1 year old.
Exclusion criteria
* Child with no necessity of surgery before 1 year old. * Medical history of cardiac surgery. * Refusal of consent by the parents. * No social security. * Child not operated on the CHU of LILLE.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Interest of pre and post surgery EEG on neurodevelopmental disorders | Age of patient : 24 Months | Evaluation of the interest of pre and post surgery EEG in the prediction of neurodevelopmental disorders on patients operated of congenital cardiopathy before the age of 1 year old. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association between orality disorders and neurodevelopmental disorders | Age of patient : 24 Months | Association between the presence of pre surgery and 1 year old orality disorder and occurence of neurodevelopmental disorders. |
| Interest of post surgery EEG neurodevelopmental disorders at 24 months old | Age of patient : 24 Months | Evaluation of the interest of 24 months old post surgery EEG in the prediction of neurodevelopmental disorders on patients operated of congenital cardiopathy before the age of 1 year old, having a normal pre surgery EEG. |
Countries
France
Contacts
CONTACTSylvie NGUYEN THE TICH, MD,PhD
CONTACTSylvie JORIOT, MD
STUDY_CHAIRFlavien GAUTRON, CRA
CHU de Lille
STUDY_CHAIRGaëlle GUYOT, CRA
CHU de Lille
Outcome results
None listed