Ischemic Stroke
Conditions
Keywords
ischemic stroke, thrombi, metabolites
Brief summary
The MATISSE (Molecular Analysis of Thrombus for Ischemic Stroke prognosis and Etiology) project evaluates the hypothesis that the molecular composition of cerebral thrombus in metabolites, lipids, and proteins conditions the clinical prognosis at 3 months of the infarction and informs on its etiological subtype
Interventions
OTHERThrombi and blood analyses
Thrombi and blood will be collected during thrombectomy
Sponsors
Assistance Publique Hopitaux De Marseille
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male or female 18 years of age or older; * Patient with a cerebral infarction documented by brain imaging who received endovascular treatment by mechanical thrombectomy; * Patient for whom it was possible to collect cerebral thrombus for LC-MS analysis during mechanical thrombectomy: * Patient who was informed of the study and formulated a non-opposition to participation. If not, patient for whom a relative was informed and formulated a non-opposition.
Exclusion criteria
* Patient with a cerebral infarction documented by cerebral imaging, having benefited from an endovascular treatment with mechanical thrombectomy that did not allow the extraction of a cerebral thrombus. * Protected persons (articles L1121-5, L1121-6 and L121-8 of the Public Health Code): pregnant or breast-feeding women, persons deprived of liberty, under guardianship or curatorship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determination and validation of molecular signatures, obtained by LC-MS analysis of cerebral thrombi, predictive of the excellent clinical prognosis | 3 months after the cerebral infarction | Rankin score (0 to 6, 6 meaning worse outcome) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Death | 3 months after cerebral infarction | Death of the patient |
| Determination of molecular signatures predictive on successful recanalization after mechanical thrombectomy | Right after the thrombectomy | Score mTICI (modified Thrombolysis In Cerebral Infarction, 0 to 3, 0 meaning worst outcome) |
| Determination and validation of molecular signatures, obtained by LC-MS analysis | 7 days after the cerebral infarction | ASCOD (atherosclerosis, small vessel disease (SVD), cardioembolism, other and dissection) description (0 to 9, 9 meaning insufficient assessment to determine the presence or absence of the disease) |
| Severe intracranial hemorrhage | 3 months after the cerebral infarction | Heildeberg classification (0 to 3d, 3d meaning subdural hemorrhage) |
| Positive infarct growth after successful recanalization | Between 24 and 48h after the thrombectomy | Quantification of infarctus volume by MRI |
| Early Neurological Deterioration | 24 hours after recanalization treatment | Worsening of at least 4 points in the NIHSS (National Institutes of Health Stroke Scale) score (0 meaning better outcome, 0 to 42) |
| Use of thrombolytic therapy in the acute phase | Before thrombectomy | Quantification of thrombolytic therapy |
| Patient exposure to peak outdoor air pollution | 96 hours before cerebral infarction | Quantification of peak outdoor air pollution (identification of the location of the patient and the polluants observed in the areas) |
| Recovery of autonomy in walking | 3 months after the cerebral infarction | Parker score (0 to 9, 9 meaning better outcome) |
Countries
France
Contacts
Primary ContactEmilie Doche
Outcome results
None listed