Arthritis, Psoriatic, Arthritis, Rheumatoid, Crystal Arthropathies
Conditions
Keywords
photon-counting detector computer tomography, magnetic resonance imaging, radiography, rheumatoid arthritis, psoriatic arthritis, crystal arthropathies
Brief summary
Chronic peripherial arthritides are common diseases with soaring public health consequences. Our goal is to assess the role of photon-counting detector computed tomography in the diagnostics of peripherial arthropathies.
Detailed description
Background: Chronic peripherial arthritides include immune-mediated (rheumatoid arthritis, psoriatic arthritis) and crystal deposition diseases (gout, pseudogout, hydroxiapatite-deposition disease). Conventional radiographs are utilized to screen arthritis-associated deformities, bone erosions and joint space narrowing. MRI is able to detect bone marrow edema, synovitis and the swelling of soft tissues. Sonography can also detect synovitis and soft tissue involvement but does not provide information about bone marrow edema and poorly assess erosions. Photon-counting detector computed tomography (PCD-CT) is a novel type of CT device which provides many advantages like improved signal-to-noise ratio, intrinsic spectral information, lower radiation exposure, and better spatial resolution. PCD-CT is a type of X-ray computed tomography in which X-rays are detected using a photon-counting detector. These detectors are able to directly transform X-ray photons into electrical signals. Compared to previous generation scintillation detectors, photon-counting detectors have several advantages: being able to count the charges created by individual x-ray photons and measuring their energy level also providing multi- energy spectral sensitivity. 0.2 mm slice thickness potentiates the detection of bone erosionss. Collagen-rich structures like cartilage, ligaments, and tendons are easier to identify on PCD-CT images. Bone marrow edema can be visualized with virtual non- calcium reconstruction. PCD-CT could both detect and differentiate cristal deposits. Aims: To assess the possible role of PCD-CT technique in the diagnostics of peripherial arthropathies.To compare the role of PCD-CT in the detection of arthritis-related pathologies with other imaging modalities like MRI and conventional radiography.
Interventions
DEVICEPhoton-counting detector-CT
CT scan
Sponsors
National Institute of Rheumatology and Physiotherapy, Hungary
Buda Hospital of the Hospitaller Order of Saint John of God
Semmelweis University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Inclusion criteria
* Rheumatoid arthritis (EULAR/ACR Criteria) / Psoriatic arthritis (CASPAR Criteria)/ Crystal arthropathies * signed informed consent
Exclusion criteria
* age: \<18 years, \> 100 years * pregnant * breastfeeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bone erosions | From baseline to at least 2 years | To assess the detection of arthritis-related bone erosions with different imaging techniques, including PCD-CT. |
| Bone marrow edema and periarticular soft tissue involvement | From baseline to at least 2 years | To assess the detection of arthritis-related bone marrow edema and periarticular soft tissue with different imaging techniques, including PCD-CT. |
| Crystal deposit characterization | From baseline to at least 2 years | To detect the different crystal deposits with PCD-CT. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To evaluate the performance of PCD-CT in the detection of active arthritis-related imaging findings and structural damages. | From baseline to at least 3 years | To compare the performance of PCD-CT with different modalities in the diagnostics of peripherial arthropathies. |
Countries
Hungary
Outcome results
None listed