Cancer
Conditions
Brief summary
The aim of the study is to evaluate and compare immune response to a single exercise intervention in cancer patients and healthy age-maged individuals.
Interventions
Endurance training adapted to age, resting heart rate
Sponsors
Universität Duisburg-Essen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
15 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Adolescents and young adults \>14 years of age * undergoing acute cancer treatment (chemotherapy) * signed informed consent
Exclusion criteria
* Inability to follow and implement test instructions * medical contraindication to HIIT on cycle ergometer * chemotherapeutic treatment 48 h prior * Hb \<8g/dl; platelets \< 20,000/ul.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Natural Killer Cells | Change from pre Intervention to immediately after intervention and 1 hour post intervention | NK cells, subgroups and innate lymphoid cells |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Subjective Quality of Life | Once after intervention | Quality of Life (EORTC QLQ-C30, questionnaire score from 0 - 100, higher score = better quality of life) |
| Fatigue | Once after intervention | Fatigue (EORTC QLQ FA12 Fatigue questionnaire range 0 - 100, higher score = worse outcome) |
| Nutritional status | Once after intervention | Mini Nutritional Assessment (MNA range 0 - 14 points), lower score = worse |
Countries
Germany
Outcome results
None listed