Alzheimer Disease, Neuro-Degenerative Disease
Conditions
Keywords
Alzheimer Disease
Brief summary
Alzheimer's disease is a severe neurodegenerative disorder of the brain that is characterized by progressive loss of memory and cognitive decline. With the ageing population, AD is a major public health problem affecting nearly 35 million people worldwide with numbers projected to rise to 115.4 million by 2050. AD is the only cause of death among the top ten causes that has no prevention or cure . It is believed that novel treatment of AD needs to start early or even at the prodromal stage in order to be effective. Therefore, there is an urgent need to find accurate methods of early detection before patients with AD develop clinical dementia. This study aims to identify biomarkers for AD in local Chinese population. this study hypothesizes blood-based proteomics, retinal imaging, ASL-MRP and tau PET can improve the accuracy and staging of AD.
Detailed description
This is a cohort study. It involves baseline and 6 yearly follow ups. At baseline, all participants will go through a list of cognitive assessments, blood taking, Brain MRI scan, Brain PET scan and retinal imaging. At the first five yearly follow ups, cognitive assessment will be performed. For the sixth yearly follow up, automatic retinal image will be performed in addition to cognitive assessment.
Interventions
None listed
Sponsors
Chinese University of Hong Kong
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Chinese ethnicity * \[For dementia group, clinical diagnosis of probable Alzheimer's disease according to recommendation from the National Institute on Aging-Alzheimer's Association workgroups (NIA-AA)
Exclusion criteria
* Clinical diagnosis of non-AD dementia * contraindication for MRI or PET
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The score change in Hong Kong List Learn Test (HKLLT) | Baseline, 1 year, 2 year, 3 year ,4 year ,5 year and 6 year visit after baseline visit | The Hong Kong List Learn Test would be administered to assess the cognitive status for all group of study subjects |
| Amount of amyloid tau with T807 tracer | Baseline | Positron emission tomography imaging with T807 tracer would quantify the amount of tau protein. tau protein is one of the biomarkers associate with Alzheimer Disease |
| The score change in Montreal Cognitive Assessment Hong Kong (HK-MoCA) | Baseline, 1 year, 2 year, 3 year ,4 year ,5 year and 6 year visit after baseline visit | The Montreal Cognitive Assessment Hong Kong would be administered to assess the cognitive status for all group of study subjects |
| The score change Clinical Dementia Rating (CDR) | Baseline, 1 year, 2 year, 3 year ,4 year ,5 year and 6 year visit after baseline visit | The Clinical Dementia Rating would be administered to assess the cognitive status for all group of study subjects |
| Amount of amyloid β with 11C-Pittsburgh compound B | Baseline | Positron emission tomography imaging with 11C-Pittsburgh compound B would quantify the amount of amyloid β. Amyloid β is one of the biomarkers associate Alzheimer Disease |
| Amount of glucose hypometabolism | Baseline | Positron emission tomography imaging with 18F-FDG tracer would quantify the amount of glucose hypometabolism. glucose hypometabolism is one of the biomarkers associate with Alzheimer Disease |
| arterial spin labeling magnetic resonance perfusion (ASL-MRP) | Baseline | Arterial spin labeling (ASL) perfusion is a MRI technique to quantify tissue blood flow of all group of subjects |
| Change of Automatic Retinal Imaging | Baseline, 6th year follow up | There is a close anatomical correlation between both the macrovascular and the microvascular blood supply to the brain and the retina, and both vascular networks share similar vascular regulatory processes. Automatic Retinal Imaging is used to investigate microcirculations in retinal |
Countries
Hong Kong
Contacts
Primary ContactPualine Kwan
Backup ContactElyia Han
Outcome results
None listed