Knee Medial Meniscus Tears
Conditions
Brief summary
The purpose was to assess knee function outcomes between physical therapy and arthroscopic partial menisectomy(APM) for Metabolic syndrome(MetS) patients with degenerative meniscus lesions(DMLs) during 12 month follow up.
Detailed description
Metabolic syndrome were diagnosed with abdominal obesity, insulin resistance with or without glucose intolerance, dyslipidemia or elevated blood pressure and widely prevalence all around the world.MetS patients were always correlated with knee osteoarthritis or cartilage volume loss. For MetS patients with DMLs, whether physical therapy was non-inferior to APM in knee function and MetS components was unknown.
Interventions
PROCEDUREphysical therapy
The exercise intervention included aerobic exercises and resistance exercise, flexibility exercises about 150 minutes for ≥2 day per week.
PROCEDUREarthroscopic partial meniscectomy
Arthroscopic partial meniscectomy surgery procedure
Sponsors
Shenzhen People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
35 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Must be age between 35 and 70 years old; * Clinical diagnosis of metabolic syndrome; * Clinical diagnosis of degenerative meniscus lesions; * Patients who has knee pain history * Knee symptoms consistent with DMLs verified on MRI * eligible for arthroscopic partial meniscectomy surgery by the examining orthopedic surgeons.
Exclusion criteria
* Must be able to have no acute knee injury such as car crash or acute sports injury; * Must be able to have no knee surgeries history; * Must be able to have no rheumatoid arthritis or serious knee osteoarthritis with deformity; * Must be able to have no contraindications to MRI; * Must be able to have no severe cardiopulmonary disease; * Must be able to have no musculoskeletal or neuromuscular impairments ; * Must be able to have good visual, hearing, or cognitive;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Kellgren-Lawrence (K/L) grade change | change from baseline up to 12 months | Kellgren-Lawrence (K/L) grade |
| serum triglycerides (TG) change | change from baseline up to 12 months | serum triglycerides (TG) (mmol/L) |
| low-density lipoprotein cholesterol (LDL-C) change | change from baseline up to 12 months | serum low-density lipoprotein cholesterol (LDL-C) (mmol/L) |
| high-density lipoprotein cholesterol (HDL-C) change | change from baseline up to 12 months | serum high-density lipoprotein cholesterol (HDL-C) (mmol/L) |
| fast blood glucose(FBG) change | change from baseline up to 12 months | serum fast blood glucose(FBG) (mmol/L) |
| Body mass index change | change from baseline up to 12 months | Body mass index(BMI) weight/height square (kg/㎡) |
| the Knee Injury and Osteoarthritis Outcome Score (KOOS) change | change from baseline up to 12 months | The Knee injury and Osteoarthritis Outcome Score (KOOS) holds five subscales including: Pain (9 items); other Symptoms (7 items); Activities of Daily Living (ADL, 17 items); Sport and Recreation function (Sport/Rec, 5 items); and knee-related Quality of Life (QoL, 4 items). Each subscale is scored separately from zero (extreme knee problems) to 100 (no knee problems) |
| the International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC Score) change | change from baseline up to 12 months | The International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC) score questionnaire contains 18 items (7 items for symptoms, 1 item for sport activity, 9 items for daily activities, and 1 item for current knee function.) The total score is transformed to a value on a scale of 0 to 100, with 100 representing the highest knee function and 0 is the worst. |
| waist circumstance change | change from baseline up to 12 months | waist circumstance (cm) |
| systolic blood pressure change | change from baseline up to 12 months | systolic blood pressure /mmHg |
| diastolic blood pressure change | change from baseline up to 12 months | diastolic blood pressure/mmHg |
| serum total cholesterol (TC) change | change from baseline up to 12 months | serum total cholesterol (TC) (mmol/L) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| symptoms score change | change from baseline up to 12 months | The minimum is 0 points, the maximum is 4 points, from extreme knee problems to no knee problems. After the score of each part is calculated separately, it is converted into a percentage score by the conversion formula. |
| activities of daily living score change | change from baseline up to 12 months | The minimum is 0 points, the maximum is 4 points, from extreme knee problems to no knee problems. After the score of each part is calculated separately, it is converted into a percentage score by the conversion formula |
| function in sport and recreation score change | change from baseline up to 12 months | The minimum is 0 points, the maximum is 4 points, from extreme knee problems to no knee problems. After the score of each part is calculated separately, it is converted into a percentage score by the conversion formula |
| knee related quality of life score change | change from baseline up to 12 months | The minimum is 0 points, the maximum is 4 points, from extreme knee problems to no knee problems. After the score of each part is calculated separately, it is converted into a percentage score by the conversion formula |
| pain score change | change from baseline up to 12 months | The minimum is 0 points, the maximum is 4 points, from extreme knee problems to no knee problems. After the score of each part is calculated separately, it is converted into a percentage score by the conversion formula. |
Countries
China
Contacts
Primary ContactHongyu Wang, Doctor
Outcome results
None listed