Heart Failure
Conditions
Keywords
Ketones, Heart
Brief summary
Does oral intake of exogenous ketone salt improve heart function measured by cardiac MRI in heart failure compared to oral intake of a carbohydrate placebo?
Detailed description
This study will help to quantify heart and kidney ketone uptake with or without an exogenous ketone salt in heart failure condition. Participants will have 2 different cardiac MRI to perform: 1. Fasting with exogenous ketone salt supplement 2. Fasting with exogenous carbohydrate supplement
Interventions
DIETARY_SUPPLEMENTexogenous ketone salt supplement
Dietary Supplement: Fasting water and with exogenous ketone salt supplement. Participants will have to take 1 doses of supplement 30 minutes before the scan.
DIETARY_SUPPLEMENTexogenous carbohydrate supplement
Dietary Supplement: Fasting water and with exogenous carbohydrate supplement. Participants will have to take 1 doses of supplement 30 minutes before the scan.
Sponsors
Nestlé Health Science
Université de Sherbrooke
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
Triple (Participant, Investigator, Outcomes Assessor) Investigators, participants and outcome assessors will be fully blinded.
Intervention model description
Crossover Assignment, Each participant will have to do the 2 Acute supplementation interventions
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with heart failure with left ventricle ejection fraction of 40% * Heart failure of ischemic or dilated etiology * Ambulatory patient with a NYHA functional class of II-III; * Stable symptoms and no change in medical therapy in the last month.
Exclusion criteria
* Diabetes * Patients treated with any SGLT2i; * Chronic kidney disease * Acute coronary syndrome in the last 3 months; * Use of parenteral inotropic agents; * Persistent or permanent atrial fibrillation or atrial flutter; * Presence of pacemaker or defibrillator; * Medical condition that causes malabsorption of the test material; * Under ketogenic diet, or using exogenous ketone supplements * Use of nicotinamide adenine dinucleotide (NAD) precursor supplements
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Left ventricle ejection fraction by cardiac MRI under acute intake of exogenous ketone salt compared with exogenous carbohydrate placebo in heart failure patients. | 15 minutes | Measure by Cardiac MR in pourcentage between diastolic and systolic volume in millimeter |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Ventricle volume by cardiac MRI after intake supplement in heart failure patients. | 15 minutes | Measure by Cardiac MR in millimeter |
| Cardiac output by cardiac MRI after intake supplement in heart failure patients. | 15 minutes | Measure by Cardiac MR in liter per minute |
| Right ventricle ejection fraction by cardiac MRI after intake supplement in heart failure patients. | 15 minutes | Measure by Cardiac MR in pourcentage between diastolic and systolic volume in millimeter |
| Effects of supplement on the blood pressure of heart failure patients | 60 minutes | Measure the blood pressure in systole and diastole in mm Hg |
| Effects of supplement on the heart rate of heart failure patients | 60 minutes | Measure the heart rate in beat per minute |
| Effects of supplement on serum biomarkers | 60 minutes | Concentration of lactate (mmol/L) |
Countries
Canada
Outcome results
None listed