Catheter-Related Infections
Conditions
Brief summary
The goal of this prospective interventional study is to evaluate the impact of antibiotic prophylaxis on bloodstream infections after liberation of extracorporeal membrane oxygenation therapy. The main questions aims to answer are: • does application of vancomycine prior to ECMO liberation have an impact of bloodstream infections? Participants will get 1 dose of vancomycine I.V. (15-20 mg per kgKG) prior to liberation of ECMO. Researchers will compare this interventional group to a group without antibiotic prophylaxis.
Interventions
DRUGVancomycine
Application of 15-20 mg per kgKG Vancomycine I.V. prior to ECMO liberation
Sponsors
Universität des Saarlandes
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* adult patients older than 18 years * ECMO-Therapy
Exclusion criteria
* patients younger than 18 years * fever \>38,5°C * pregnancy * antibiotic treatment with Vancomycine, Linezolid, Daptomycin or Tygacil on the day of liberation * prior adverse events after application of Vancomycine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Growth of pathogens in blood culture | taken 72 hours after liberation of extracorporeal membrane oxygenation therapy | Detection of pathogens / blood stream infection |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Growth of pathogens on cannula tip | on the day of liberation, cannula tip will be send to institute of microbiology directly after liberation from ECMO | Detection of growth of pathogens on cannulas |
| laboratory parameters | 6.00 am on the day of liberation of extracorporeal membrane oxygenation therapy | leukocytes, procalcitonin, C-reactive protein |
Countries
Germany
Contacts
Primary ContactCarsten Zeiner, MD
Backup ContactPhilipp M Lepper, MD
Outcome results
None listed