Changes in Tactile Perception in People With Segmental Exclusion Syndrome

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05650398

Enrollment

Registered

2022-12-14

Start date

2022-09-26

Completion date

2025-02-15

Last updated

2025-08-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Upper Limb Exclusion Syndrom

Brief summary

Segmental exclusion syndrome is characterised by the non-use or under-use of a limb segment, most oftenly reported in the distal part, following an injury, without affecting the central nervous system. This syndrome has an important negative impact on the daily life of affected subjects; however, it remains poorly studied, particularly in terms of pathophysiology, and its management is still not specific. Currently, the main pathophysiological hypothesis is an alteration of the afferences related to a dysfunction of the sensorimotor loop. An hypothesis is that this dysfunction could concern the level of tactile perception and that the damage to the distal light touch receptors could play a role in the pathophysiology. The protocol is based on the performance of tests that explore different aspects of light touch: passive, active, dynamic and static sensitivity.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* No history of upper limb involvement * Confirmed diagnosis of segmental exclusion \> 3 months after injury (2 items assigned to 400 points) * Able to understand simple orders

Exclusion criteria

* Central neurological involvement after the initial or pre-existing injury * Truncal nerve damage * Presence of psychiatric pathology * Communication and/or comprehension disorders * Presence of other pathology that may lead to sensory disorders (complicated diabetes, ductal syndrome, ...)

Design outcomes

Primary

Measure	Time frame	Description
Difference in passive sensitivity discrimination orientation threshold between each hand in static condition.	once during the one-day evaluation session	Difference in thresholds of sensitive discrimination between the two hands in the Grating Orientation Task (mm)
Difference in passive sensitivity discrimination threshold between each hand in static condition.	once during the one-day evaluation session	Difference in thresholds of sensitive discrimination between the two hands in the Static Two Points discrimination test (mm)
Difference in passive sensitivity discrimination of pressure threshold between each hand in static condition.	once during the one-day evaluation session	Difference in thresholds of sensitive discrimination between the two hands in the monofilament test (Newton)
Difference in passive sensitivity discrimination threshold between each hand in dynamic condition.	once during the one-day evaluation session	Difference in thresholds of sensitive discrimination between the two hands in Moving Two-Points Discrimination Test (mm)

Secondary

Measure	Time frame	Description
Difference in active sensitivity discrimination threshold between each hand in dynamic condition.	During the evaluation session	Percentage of correct answers to the bar test in both groups.

Countries

France

Outcome results