Hepatocellular Carcinoma, Perioperative Complication, Vitamin D Deficiency
Conditions
Keywords
Vitamin d therapy, Hepatocellular Carcinoma, Perioperative Complication
Brief summary
The goal of this double-blind, randomized controlled trial is to test the effect of short-term and high-dose vitamin D therapy in patients undergoing hepatectomy for hepatocellular carcinoma.
Detailed description
Participants will receive short-term high dose of vitamin D during perioperative period. The main questions the study aims to answer are: 1. If vitamin D therapy benefits perioperative care 2. If short-term high dose of vitamin D supplement is safe
Interventions
DIETARY_SUPPLEMENTVitamin D
576 000 IU D 5-7 days prior to the surgery and 144 000 IU daily on post-operative day 1-2
DIETARY_SUPPLEMENTPlacebo
An equal volume of medium chain triglyceride (MCT, as placebo) to vitamin D 5-7 days prior to the surgery and on the post-operative day 1-2.
Sponsors
Taipei Veterans General Hospital, Taiwan
National Taiwan University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients older than 20 years * Patients will undergo hepatectomy for hepatocellular carcinoma.
Exclusion criteria
* Patients with hypercalcemia, hyperparathyroidism, sarcoidosis, multiple myeloma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Infection rate | Perioperative period | Diagnosed by clinical presentation and relevant biomarker |
Contacts
Primary ContactYin-Yi Han, PHD
Outcome results
None listed