Effects of Intrathecal Local Anesthetics on Left Ventricular Global Longitudinal Strain

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05650008

Enrollment

Registered

2022-12-14

Start date

2023-02-01

Completion date

2023-10-10

Last updated

2023-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Global Cardiac Wall Motion Dysfunction, Left Ventricular Dysfunction, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use

Keywords

Strain

Brief summary

The objective of this study is to assess the effects of intrathecal local anesthetics on left ventricular global longitudinal strain (LVGLS) using transthoracic echocardiography (TTE).

Interventions

DRUGIntrathecal local anesthesia

Administration of local anesthetic into intrathecal space to achieve surgical anesthesia

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Adult patients undergoing elective knee and hip replacements under spinal anesthesia

Exclusion criteria

* Patients who do not wish to consent * Patients with contraindications to TTE * Patients with reduced left ventricular systolic function as defined by LV ejection fraction \< 50% on pre-operative echocardiography * Patients with body mass index greater than 40 * Non-English-speaking subjects * Cognitively impaired adults

Design outcomes

Primary

Measure	Time frame
Left Ventricular Global Longitudinal Strain	5 minutes

Secondary

Measure	Time frame
Left Ventricular Ejection Fraction	5 minutes

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026