Motor Activity, Stroke
Conditions
Keywords
Stroke, Motor dysfunction, MRI, structural connectivity, functional connectivity
Brief summary
The current study aims to reveal the SC-FC coupling pattern and its relationship with motor function in post-stroke survivors with motor dysfunction by multimodal MRI.
Detailed description
Stroke is the leading cause of death and disability in China. Recently, many previous studies suggested exploring the functional reorganization of the motor function among post-stroke survivors is urgent to be solved in both clinical work and applied basic research. Investigating the structural connectivity (SC) of the brain could visualize the anatomical connections between different brain regions and exploring the functional connectivity (FC) could reveal the functional activity patterns of the human brain in resting- and task- states. Previous studies suggested that SC-FC coupling analysis may shed light on exploring biological markers for the assessment and treatment of motor deficits in post-stroke survivors. The current study aims to reveal the SC-FC coupling pattern and its relationship with motor function in post-stroke survivors with motor dysfunction by multimodal MRI.
Interventions
None listed
Sponsors
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
30 Years to 75 Years
Inclusion criteria
1. Comply with the diagnostic criteria of Stroke in the 2010 Guidelines for the Prevention and Treatment of Cerebrovascular Diseases in China, and confirmed by head CT or MRI. 2. First onset unilateral subcortical stroke (basal ganglia, thalamus, internal capsule, corona radiata, lateral ventricles, etc.). 3. Age ranged from 30 to 75 years old. 4. Right-handedness before stroke. 5. Greater than three months since stroke onset and Brunnstrom graded as III-VI; 6. The condition and vital signs are stable. 7\. Sign the informed consent form.
Exclusion criteria
1. Any contraindications for the MRI examination. 2. History of other brain diseases and drug dependency. 3. Unstable conditions or accompanied by malignant and rapidly progressing diseases, such as severe atrial fibrillation. 4. Serious communication barriers, cognitive impairment, or cooperation with difficulties.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Structural-functional Connectivity Coupling | Within 1 week after enrollment | The coupling between structural connectivity and functional connectivity |
| Fugl-Meyer Assessment | Within 1 week after enrollment | Assessing the motor function in post-stroke participants |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Chinese version of Modified Barthel Index | Within 1 week after enrollment | Assessing the activities of daily living in post-stroke participants |
| Broetz Hand Test | Within 1 week after enrollment | Assessing the hemiplegic hand performance in post-stroke participants |
| Placebo Questionnaire | Within 1 week after enrollment | Self-evaluation of rehabilitation treatment in post-stroke participants |
| Hamilton Depression Rating Scale | Within 1 week after enrollment | Assessing the depression in post-stroke participants |
| Chinese (Putonghua) Version of Oxford Cognitive Screen | Within 1 week after enrollment | Assessing the cognition in post-stroke participants |
Countries
China
Contacts
Primary ContactWenjun Hong
Outcome results
None listed