Acute Kidney Injury
Conditions
Brief summary
Renal lithium clearance is hypothesized to be a useful indicator of renal tubular function. In this study lithium clearance will be monitored in patients with sepsis associated acute kidney injury and in healthy controls.
Detailed description
Lithium is almost completely reabsorbed in the proximal tubule in parallel with sodium and water. What is not reabsorbed here is assumed to be fully excreted in urine, giving a reasonably accurate measurement of sodium reabsorption in the proximal tubule. Endogenous lithium clearance will be measured by inductively coupled plasma mass spectrometry (ICP-MS). The Gomez equations will be applied to calculate efferent arteriolar resistance, afferent arteriolar resistance, glomerular hydrostatic pressure, glomerular filtration pressure, and glomerular oncotic pressure. N-acetyl-β-D glucosaminidase (NAG) and NGAL, markers of tubular injury, will be measured by a spectrophotometric method using a commercially available kit. Routine blood and urine analyses will be performed at the Diagnostic Clinic Laboratory, University Hospital of North Norway, Tromsø.
Interventions
DIAGNOSTIC_TESTLithium measures
Measurements of lithium levels in blood and urine
Sponsors
University Hospital of North Norway
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
sepsis associated acute kidney injury: * Sepsis diagnosed or suspected * Age \>18 years Inclusion Criteria healthy controls: * Previously healthy individuals * Age \>18 years
Exclusion criteria
Oliguria or renal impairment due to other causes than sepsis. Pregnancy or breast-feeding.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Renal lithium clearance | Repeated measures between 07:00-20:00 | Measurement of renal lithium clearance at 8AM, 2 PM, and 8 PM |
Countries
Norway
Outcome results
None listed