Lung Injury, Acute, Ultrasound Therapy; Complications
Conditions
Keywords
lung consolidation, respiratory failure, perfusion
Brief summary
The aim of this study is to evaluate the potential usefulness of lung ultrasound to assess the size and perfusion of consolidation and explore their relationships with clinical outcome.
Detailed description
Lung consolidation is one of the most causes of hypoxia in intensive care unit(ICU) settings. A quantitative measurement of consolidation would be extremely benefit for the clinical management in hypoxemia, both as an index of severity and to predict outcomes.In order to quantify the lung consolidation and its effect on clinical outcomes, a simple and quantitative scoring system of the size and perfusion of lung consolidation was proposed by lung ultrasound. Subjects with respiratory failure and lung consolidation proved by chest imaging underwent lung ultrasound examination. The size of consolidation and the richness of blood flow was computed upon lung ultrasound. The sensitivity, specificity and accuracy of the scoring system were calculated and compared to evaluate the diagnostic efficacy.
Interventions
DIAGNOSTIC_TESTUltrasound
Each patient underwent ultrasound after admission of ICU.
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
1. Admission to ICU( 18yr\<age\<90yr); 2. Patients presented with acute respiratory failure; 3. Pulmonary consolidation by chest imaging (lung ultrasound, X ray or CT scan).
Exclusion criteria
1. Hemodynamic instability (i.e., severe hypotension with systolic arterial pressure\<60mmHg despite fluid expansion and vasoactive support; systolic arterial pressure\>180mmHg; uncontrolled cardiac arrhythmias); 2. Severe thoracic trauma; 3. Coronavirus disease 2019; 4. Pulmonary artery hypertension and pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| consolidation area index | through study completion, an average of 2 year | The volume of consolidation was measured by consolidation area index (CAI) which is calculated from two-dimensional measures, namely the product of the core distance (from the bottom to the top of the screen) and the longitudinal distance (from the left to the right of the screen). |
| blood flow score | through study completion, an average of 2 year | A semi-quantified scoring system based on the richness of flow signals was established. It identifies four progressive steps of blood signals, each corresponding to a score: no pulsatile blood flow-score 0; sparse dot-like blood flow-score 1; pronounced curvilinear vascularity-score 2; tree-like vascularity-score 3. |
Countries
China
Contacts
Primary ContactNa Wang, MD
Backup ContactHuaiwu He, MD
Outcome results
None listed