Cardiovascular Diseases, Periodontal Diseases
Conditions
Brief summary
Asprosin, a recently discovered glucogenic adipokine, is mainly synthesized by white adipose tissue and released during fasting. Appetite, glucose metabolism, insulin resistance, cell apoptosis, etc. asprosin is associated with diseases such as diabetes, obesity, polycystic ovary syndrome, and cardiovascular diseases. Periodontal tissue may act as a source of endocrine-like inflammatory mediators (such as TNF-α, IL-6 and IL-1) that are important in periodontal inflammation and can affect glucose and lipid metabolism. Production of TNF-α and IL-6 in adipose tissues strengthens the relationship between cardiovascular diseases and periodontitis. Investigators postulated that asprosin may be a candidate for explaining the triangular relationship between cardiovascular and periodontal disease.
Detailed description
Periodontal disease is a chronic, multifactorial, and infectious disease caused by bacteria. It is characterized by the formation of an inflammatory response in the supporting bone and connective tissue against microbial dental plaque, and the nature of the resulting inflammatory response determines the course of periodontal disease. Cardiovascular and periodontal diseases are closely related, presenting a triad association. Asprosin circulates in the blood at nanomolar levels and is taken to the liver, where it activatesinvestigators the G protein-cAMP-PKA pathway, causing rapid glucose release into the circulation.
Interventions
DIAGNOSTIC_TESTSerum samples will be collected. Asprosin levels will be determined by biochemical analysis
Serum samples will be collected from both groups for biochemical analysis.
Sponsors
Ataturk University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
For Healthy group * All individuals were generally healthy, * non-smoking For Myocard Infarctus group * patients with ST elevation of Myocardial Infactus * patient with less than ten teeth
Exclusion criteria
* Smokers or those with diabetes or other inflammatory disease * Pregnant or breastfeeding women * None had undergone periodontal therapy and/or antibiotic therapy in the past 6 months. * None has a contagious disease such as HIV or AIDS
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Asprosin Levels | two weeks | Determination of asprosin levels by making biochemical analyzes from serum |
Countries
Turkey (Türkiye)
Outcome results
None listed