Effects of Different Deflation Methods on Coughing Response and Hemodynamics During Extubation

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05647395

Enrollment

Registered

2022-12-12

Start date

2022-10-01

Completion date

2024-07-30

Last updated

2022-12-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Deflating Method

Keywords

Deflating method, Extubation phase, Coughing reaction

Brief summary

Patients with endotracheal intubation and general anesthesia often have severe choking and hemodynamic fluctuations during the extubation period, which increases the risk of cerebrovascular accident, arrhythmia, incision bleeding and so on . This study aimed to observe the effects of different methods of deflating of endotracheal tube cuffs on cough response and hemodynamics during periextubation in patients undergoing general anesthesia surgery.

Interventions

BEHAVIORALTracheal tube cuffs differ in deflation

When removing the endotracheal tube, the gas in the cuff is drawn at a uniform and slow pace

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

1. Elective endotracheal intubation under general anesthesia. 2. Operation time \< 3 h. 3. ASA grade I or II. 4. Age 18\ 65 years old.

Exclusion criteria

1. Throat and neck surgery. 2. Those assessed to have a high risk of reflux aspiration. 3. Difficulty intubation. 4. History of snoring before surgery. 5. Recent respiratory illness such as chronic cough. 6. Previous airway hyperresponsiveness, such as asthma. 7. recent use of cough suppressants. 8. Patients with severe heart, liver and kidney diseases.

Design outcomes

Primary

Measure	Time frame	Description
Grading of cough reaction	During extubation procedure	Grading of cough reactions
Change in Blood pressure	Preoperatively, immediately before extubation, immediately after extubation, 1 minute after extubation, 3 minutes after extubation, 10 minutes after extubation	Hemodynamics
Change in Heart rate	Preoperatively, immediately before extubation, immediately after extubation, 1 minute after extubation, 3 minutes after extubation, 10 minutes after extubation	Hemodynamics

Secondary

Measure	Time frame	Description
Adverse reactions	Within 24 hours after removal of the endotracheal tube	Hypoventilation, pharyngeal discomfort, hoarseness

Countries

China

Contacts

Primary ContactZhuan Zhang

zhangzhuancg@163.com+8615062791355

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026