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Lung Cancer Screening in Family Members and Peers of Lung Cancer Patients: a Prospective Cohort Study

Lung Cancer Screening in Family Members and Peers of Lung Cancer Patients: a Prospective Cohort Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05645731
Enrollment
100
Registered
2022-12-09
Start date
2023-05-12
Completion date
2025-04-01
Last updated
2025-08-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Cancer, Lung Cancer Screening, Patient Empowerment

Brief summary

Lung cancer screening of active or former heavy smokers with yearly low-dose CT allows for earlier diagnosis and better lung cancer survival. Risk of developing lung cancer is higher among family members and close contacts of lung cancer patients, because of shared genetics, environment and life habits like smoking. The investigators want to engage lung cancer patients to refer their family members and close contacts for lung cancer screening, and evaluate if this referred population have higher risk of lung cancer than the population referred by their family doctors.

Interventions

None listed

Sponsors

Nicole Ezer, MD, FRCPC, MPH
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

Lung cancer patients: Inclusion Criteria: * \> 18 years old * Current or former lung cancer patient

Exclusion criteria

none Referred participants Inclusion criteria: \>18 years old

Design outcomes

Primary

MeasureTime frameDescription
Mean number of referrals for lung cancer screening per participants2 weeks post inclusionMean number of referrals for lung cancer screening per participants: lung cancer participants will refer contacts directly on the REDCap questionnaire at enrollment. They will be contacted a second time 2 weeks after enrollment and asked if they referred additional people in their entourage for lung cancer screening.
Mean PLCOm2012 risk prediction model score among referred participantsbaselineMean risk of developing lung cancer in the next 6 years using the validated PLCOm2012 risk prediction model in smokers or ex-smokers referred participants that are 55 to 74 years old.

Secondary

MeasureTime frameDescription
Number of referred participants who enrolled in the study.6 monthsNumber of referred participants who enrolled in the study.
PLCO score as a binary outcome (above or below 2%) among referred participantsbaseline
Proportion of LCS eligible participants who will complete lung cancer screening within 18 months of referral by a lung cancer patient18 monthsProportion of LCS eligible participants who will complete lung cancer screening within 18 months of referral by a lung cancer patient
Number of visitors on our website for referred participants6 monthsQuantification of people who visited the website for close contacts of lung cancer patients: Number of unique access to website based on google analytics data.
Proportion of individuals who demonstrate interest in referral to a smoking cessation program among referred participants that are current smokersbaselineProportion of individuals who demonstrate interest in referral to a smoking cessation program among referred participants that are current smokers
Anxiety regarding lung cancer for referred participantsbaselineGAD7
Proportion of individuals who would theoretically demonstrate interest in genetic testing to assess for lung cancer risk.baselineProportion of individuals who would theoretically demonstrate interest in genetic testing to assess for lung cancer risk.
Number of people who started to fill the enrollment form for referred participants.6 monthsNumber of people who started to fill the enrollment form for referred participants.

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 5, 2026