Autoimmune Encephalitis, Paraneoplastic Syndromes
Conditions
Keywords
Neurological paraneoplastic syndrome, auto immune encephalitis, Ma2 antibody
Brief summary
Paraneoplastic neurological syndromes (PNS) are rare complications of cancer occurring in 0.01% of cases. Their clinical, biological and radiological presentation is heterogeneous and may constitute a diagnostic challenge. Anti-Ma2 PNS are rare diseases with a guarded prognosis. They are most often associated with a seminoma-like testicular tumor but can also be associated with lung cancer. Classically, they present as limbic, diencephalic and/or brainstem encephalitis. Anti-Ma2 antibodies target intracellular receptors and are characteristic of a particular form of encephalitis. Atypical manifestations including narcolepsy-cataplexy, weight gain, sexual dysfunction and motor neuron syndrome have been described and explain the difficulty in diagnosing anti-Ma2 associated PNS. It seems interesting to better characterize the phenotypes of Ma2 patients in order to optimize the diagnosis and follow-up.
Interventions
DIAGNOSTIC_TESTDiagnosis test
Tests can be used: immunofluorescence, immunodot, western blot, tests CBA on sera or CSF.
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Neurological disorder * Anti-Ma2 positivity in sera or CSF * Patient \> 18 years old
Exclusion criteria
* Patient without clinical data * Patient without Ma2 antibody in sera or CSF
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rankin score | 12 month after diagnosis | Follow up and survival (rankin score) |
Countries
France
Outcome results
None listed