Diet, Healthy, Oncogenesis, Urinary Bladder Diseases
Conditions
Brief summary
The goal of this interventional study is to test the influence of food intake with characteristics of the urinary bladder. The main questions it aims to answer are: * How does food intake modify the characteristics of urothelial cells? * Does change of specific diet regimes influence biomarker characteristics in urine? Participants will follow specific diet regime for a given time period. After completion of this period biomarker assessment is performed. Thereafter the participants follow an opposite diet regime for the same time period with identical biomarker assessment at the end. Biomarkers within the participants and between the diet regimes will be compared to investigate the influence of food intake on the urinary bladder.
Interventions
OTHERDietary regimens
Food intake will follow a recommendation according to a specific list. Protective and non-protective food intake will be performed for specific time periods with biomarker assessment after each period.
Sponsors
Roland Seiler-Blarer
Study design
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* no daily medication * no ongoing medical treatment
Exclusion criteria
* Chronic disease * Regular medication * Not willing to follow diet instructions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in molecular profile of urothelial cells | 12 weeks | After the 12 week diet period (protective and non-protective), cells voided in urine will be sampled and examined. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| DNA sequences in urinary microbiome | 12 weeks | After the 12 week diet period (protective and non-protective), DNA sequencing on urinary microbiome in voided urine will be performed and compared between the different dietary regimens. |
| Change of BMI | 12 weeks | After the 12 week diet period (protective and non-protective) BMI will be assessed. |
| Change in multiplex cytokine levels in voided urine | 12 weeks | After the 12 week diet period (protective and non-protective), supernatant in voided urine will be used for further examination |
| Change of blood pressure | 12 weeks | After the 12 week diet period (protective and non-protective), systolic and diastolic blood pressure will be assessed. |
| Change of health status | 12 weeks | After the 12 week diet period (protective and non-protective), health status will be assessed using the Short Form 36 (SF-36) questionaire. The possible score ranges from 0 to 100 points, with 0 points representing the greatest possible health limitation, and 100 points representing no health limitation. |
| Change of heart rate | 12 weeks | After the 12 week diet period (protective and non-protective), heart rate will be assessed. |
Countries
Switzerland
Outcome results
None listed