Retinal Toxicity
Conditions
Keywords
retinal toxicity
Brief summary
Current clinical cameras do not allow clinicians to see the cells of the retina. This study will evaluate a new electronic camera's ability to observe the human retina in finer detail.
Detailed description
This research study will (1) test the ability of a new electronic camera developed in Dr. Miller's laboratory to observe retina in human subjects, and (2) use the camera for observing disease in the eye. This new camera integrates cutting-edge technologies in adaptive optics (AO) and optical coherence tomography (OCT) that enable the camera to capture sharp images. The objective of our study is to find out (1) whether the AO-OCT camera will allow researchers to observe the retina with finer resolution than current clinical cameras, and (2) whether this finer detail is useful for observing the progression of disease in the eye. To address the second objective, the study will subjects with various disease severity of drusen associated geographic atrophy.
Interventions
DEVICEAdaptive Optics - Optical Coherence Tomography (AO-OCT) retinal imaging
AO-OCT used in this study is an investigational OCT imaging system. In this instrument, ocular aberration sensing and correction is achieved with a Shack-Hartmann wavefront sensor (SHWS) and deformable mirror, respectively. A pupil camera and fixation target are used to position the participant's head and eye for scanning a particular retinal region within 15 degrees of the fovea. Data collected generally includes AO-OCT volume videos and SHWS measurements of ocular aberrations.
Sponsors
Indiana University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DEVICE_FEASIBILITY
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Retinal disease of either inherited retinal degeneration or retinal toxicity
Exclusion criteria
* Ocular media opacities * High refractive error * Pupil dilation imposes a risk to ocular health
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cone Photoreceptor Dysfunction | 2 years | Images will be used to determine changes in cone photoreceptor dysfunction and death |
| Quality of photoreceptor and retinal pigment epithelium (RPE) cell layers | 2 years | Images of the photoreceptor and RPE cell layers taken with clinical instruments and the AO-OCT will be compared. |
| RPE cell morphology changes | 2 years | Images will be used to determine the changes in RPE cell morphology in regions of healthy and diseased retina (in subjects with retinal disease). |
Countries
United States
Outcome results
None listed