Comparison of Perioperative Analgesic Efficacy of Femoral Nerve Block, Adductor Canal Block and 4in1 Block

Comparison of Perioperative Analgesic Efficacy in Patients Who Had Femoral Nerve Block, Adductor Canal Block and 4in1 Block Applied in Knee Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05643040

Enrollment

Registered

2022-12-08

Start date

2022-09-01

Completion date

2025-06-30

Last updated

2025-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgesia, Block

Keywords

4 in 1 block, femoral block, adductor canal block

Brief summary

Central neuraxial and regional anesthesia and analgesia techniques significantly reduce perioperative morbidity and mortality in the knee and below-knee surgeries.Nerve blocks appear to have better analgesic efficacy compared to placebo or patient-controlled analgesia (PCA). In addition, opioid-related side effects such as postoperative nausea, vomiting, pruritus, sedation, and respiratory depression are less. Therefore, interest in regional blocks such as femoral, sciatic, adductor, combined femoral, and sciatic is increasing. The knee joint is innervated by various nerves (genicular nerves) from the femoral, obturator, and sciatic nerves, and a comprehensive but simple technique is needed for postoperative analgesia. Complete and comprehensive postoperative analgesia was possible with this block, a simple single injection technique. The aim of our study is to evaluate the intraoperative analgesia efficacy of femoral, adductor canal block, and 4in1 block in patients who will undergo knee surgery.

Interventions

OTHERfemoral nerve block

To evaluate the intraoperative analgesia effectiveness of femoral block in patients who will have knee surgery.

OTHERadductor canal block

To evaluate the intraoperative analgesia effectiveness of adductor canal block in patients who will have knee surgery.

OTHER4in1 block

To evaluate the intraoperative analgesia effectiveness of 4in1 block in patients who will have knee surgery.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

SINGLE (Subject)

Intervention model description

Group I: Femoral nerve block Group II: Adductor canal block Group III: 4in1 block

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

Inclusion criteria

* Patients between the ages of \>18 * undergone knee surgery * American Society of Anesthesiologists (ASA) classification I-III group.

Exclusion criteria

* Patients who do not want to participate in the study coagulopathy peripheral neuropathy local anesthetic drug allergy chronic opioid users anticoagulant users pregnant patients

Design outcomes

Primary

Measure	Time frame	Description
intraoperative analgesia efficacy	perioperative period	The aim of our study is to evaluate the intraoperative analgesia efficacy of femoral, adductor canal block and 4in1 block in patients who will undergo knee surgery.

Secondary

Measure	Time frame	Description
postoperative analgesia efficacy	perioperative period	The aim of our study is to evaluate the postoperative analgesia efficacy of femoral, adductor canal block and 4in1 block in patients who will undergo knee surgery.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026