Observational Study of Exposure to Environmental Toxicants Among Firefighters

Evaluate the Exposure to Toxicants Emitted During a Structural Fire Assessed by Urinary and Buccal Cell Biomarkers Found in Firefighters.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05643014

Enrollment

Registered

2022-12-08

Start date

2020-02-01

Completion date

2027-12-31

Last updated

2026-03-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

PAH, 1-HOP, PheT, SPMA

Brief summary

Observational, within subject study design with 1 pre and 2 post-fire exposure biomarker samples collected to assess exposure to toxicants from combustion emissions related to fighting a structural fire.

Interventions

OTHERSample collection

This study will involve three sample collections including buccal cells and urine samples

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Firefighter (career or volunteer) * Over 18 years of age * Able to provide written voluntary consent

Exclusion criteria

* Unwilling to provide a pre and post-exposure urine sample * Current cancer diagnosis * Tobacco use within the last 1 year (verified by urinary TNEs)

Design outcomes

Primary

Measure	Time frame	Description
Studying biomarker levels in firefighters pre and post fire call.	48 months	The investigators will evaluate the differences between mean pre-exposure biomarker levels and post-exposure levels in urine and buccal samples collected within 24 hours post-exposure and 1-week post-exposure respectively using t-tests to test for statistical significance.

Countries

United States

Contacts

CONTACTJoni Jensen

jense010@umn.edu612-624-5178

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 13, 2026