Alzheimer Disease, Glucose Metabolism
Conditions
Keywords
Nutritional intervention, Glucose monitoring, Reduced carb diet, Energy metabolism, Ketones
Brief summary
The purpose of this study is to assess whether it is possible to carry out a research project with a nutritional intervention in senior's residence. Life in a small community is very different and above all unique, which could be an asset in a research setting.
Detailed description
To ensure its functioning, the brain needs a lot of energy. However, during aging, it has difficulty properly using its main fuel, sugar. The brain then becomes starved. This energy deficit is part of the vicious circle leading to memory problems. The brain, like a hybrid car, can run on two fuels, sugar and ketones. Providing alternative fuel to the brain, in the form of ketones, and thus offsetting the energy it needs, could improve its functioning and help prevent or improve memory problems. There are several ways to increase ketones in our body such as certain dietary oils, natural health products, physical activity or certain diets. Reducing the amount of sugar in our diet is also a strategy that can increase ketones. A low-sugar diet is already widely used in the prevention of several important diseases, including type 2 diabetes and even Alzheimer's disease. This study will assess the feasibility of a community intervention project in a seniors' residence with the eventual overall objective of slowing the progression or onset of AD and related health indicators, through a dietary modification. This feasibility study will last 6 months. The basic characteristics of interested participants will be collected. The global spheres of evaluation are the following: metabolic profile, cognition, quality of life and nutritional status. Glucose measurements will be taken continuously via a sensor over two weeks during the project.
Interventions
DIETARY_SUPPLEMENTlow carb diet
low carb meals will be 50% less carbs than the regular meals
DIETARY_SUPPLEMENTRegular diet
Regular diet
Sponsors
Nestlé Health Science
Université de Sherbrooke
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
All participants will go through 10 days of control diet and 10 days of reduced carb diet.
Eligibility
Sex/Gender
ALL
Age
60 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Older men or women resident of Grace Village and resident of Vü; * Understand, read and write French or English; * Possess sufficient visual and auditory acuity to pass the cognitive tests.
Exclusion criteria
* The minimum possible criteria ensuring the safety of voluntary participants. The family doctor will need to confirm eligibility. * Body mass index \< 22 * Malnutrition. * High risk of hypoglycaemia * Moderate to severe digestive diseases that can be aggravated by dietary changes * Severe dysphagia * Supplementation with MCT oil, ketone salts, ketone ester, adherence to the ketogenic diet, intermittent fasting, or other diet or supplements that may significantly increase ketones; * Participation in other intervention research projects on nutrition or aimed at metabolic change simultaneously.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood glucose concentrations | over 10 days | in mmol/L |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate | 8 hours a day during 10 days | beats per minutes |
| Number of steps | 8 hours a day during 10 days | — |
Other
| Measure | Time frame | Description |
|---|---|---|
| Menu appreciation level | After le 10 days of low carb diet | To measure feasibility of the study |
Countries
Canada
Outcome results
None listed