Growth Retardation
Conditions
Keywords
Antenatal corticosteroid therapy, newborn, growth
Brief summary
Use of antenatal corticosteroids therapy has increased since the 2000s. The benefits of such a therapy on premature newborns are scientifically and internationally recognized. Nevertheless, few studies have been conducted to investigate the impact of this antenatal corticosteroid therapy on full-term newborns (\> 36 weeks' gestation). The aim of this study is to compare the birth parameters of full-term newborns exposed or not to antenatal corticosteroid therapy.
Detailed description
All children included in the study were born at the Regional Maternity Hospital of Nancy between January 1, 2014 and December 31, 2020. One hundred and twenty-one of them were exposed during pregnancy to antenatal corticosteroids therapy and constitute the exposed arm, whereas 242 were not and constitute the non-exposed arm. Data were collected retrospectively regarding history of pregnancy, birth parameters and neonatal adaptation.
Interventions
DRUGBetamethasone
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 12 Months
Inclusion criteria
* all children exposed to an antenatal corticosteroid therapy before 34 weeks of amenorrhea because of a threat of premature delivery * only full-term newborns
Exclusion criteria
* all children exposed to an antenatal corticosteroid therapy before 34 weeks of amenorrhea for other reasons
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluate the impact of an antenatal corticosteroid therapy on head growth. | Birth | head circumference |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluate the impact of an antenatal corticosteroid therapy on fetal growth | birth | birth lenght |
| Evaluate the impact of an antenatal corticosteroid therapy on neonatal adaptation : APGAR score for each patient | birth | APGAR score |
| Evaluate the impact of an antenatal corticosteroid therapy on risk of hypoglycemia : number of patients with neonatal hypoglycémia | first 5 days | hypoglycemia |
| Evaluate the impact of an antenatal corticosteroid therapy on fetal weight | Birth | birth weight |
| Evaluate the impact of an antenatal corticosteroid therapy on neonatal outcome : number of days of hospitalisation after birth | first 5 days | day of hospitalisations after birth |
| Evaluate the impact of an antenatal corticosteroid therapy on eating disorders (number of patients with difficulty to drink) | first 5 days | eating disorders |
| Evaluate the impact of an antenatal corticosteroid therapy on risk of hypocalcemia : number of patients with hypoglycemia | first 5 days | hypocalcemia |
Outcome results
None listed