Effect of Injectable Platelet-rich Fibrin on Disc Displacement Without Reduction

Effect of Intra-articular Injection of Injectable Platelet-rich Fibrin on Disc Displacement Without Reduction

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05640206

Enrollment

Registered

2022-12-07

Start date

2019-10-01

Completion date

2021-07-01

Last updated

2022-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disc Disorder

Brief summary

This randomized clinical study was conducted on patients with disc displacement without reduction. Patient was selected one of the two study groups: control group received only arthrocentesis or test group received arthrocentesis + injectable platelet-rich fibrin (i-PRF). As primary outcome variable, pain was recorded at preoperatively and at postoperatively 1, 2, 3, 6 and 12 months. Maximum mouth opening, lateral and protrusive movements were formed as secondary outcome variables.

Detailed description

This randomized clinical study was conducted on patients with disc displacement without reduction. Patient was selected one of the two study groups: control group received only arthrocentesis or test group received arthrocentesis + i-PRF. Arthrocentesis procedure was performed for all groups with two needle technique. For test group, intra-articular i-PRF was made. As a primary outcome variable, pain was recorded at preoperatively and at postoperatively 1, 2, 3, 6 and 12 months. Maximum mouth opening, lateral and protrusive movements were formed as secondary outcome variables.

Interventions

PROCEDUREi-PRF

Arthrocentesis performed with two-needle technique, and then injection of i-PRF intra-articularly

PROCEDUREArthrocentesis

Arthrocentesis performed with two-needle technique

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* unilateral or bilateral disc displacement without reduction * localized pain on temporomandibular joint * decreased mouth opening, lateral and protrusive movements

Exclusion criteria

* Malignant or inflammatory disorders * prior surgical history of temporomandibular joint

Design outcomes

Primary

Measure	Time frame	Description
Change of pain	at preoperatively, and at 1, 2, 3, 6 and 12 months postoperatively	Pain was measured with a 10-point visual analogue scale which range from 0 meaning no pain to 10 meaning worst pain at preoperatively and at 1, 2, 3, 6 and 12 months postoperatively

Secondary

Measure	Time frame	Description
Change of maximum mouth opening	at preoperatively, and at 1, 2, 3, 6 and 12 months postoperatively	Maximum mouth opening was measured with a millimeter ruler at preoperatively and at 1, 2, 3, 6 and 12 months postoperatively
Change of lateral movements	at preoperatively, and at 1, 2, 3, 6 and 12 months postoperatively	Lateral movements were measured with a millimeter ruler at preoperatively and at 1, 2, 3, 6 and 12 months postoperatively
Change of protrusive movements	at preoperatively, and at 1, 2, 3, 6 and 12 months postoperatively	Protrusive movements were measured with a millimeter ruler at preoperatively and at 1, 2, 3, 6 and 12 months postoperatively

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026