Primary Obstructive Megaureter Management in Eastern Interregional Area

Primary Obstructive Megaureter Management in Eastern Interregional Area : Current Status and Perspectives

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05639283

Acronym

POMME

Enrollment

120

Registered

2022-12-06

Start date

2020-09-02

Completion date

2022-03-31

Last updated

2023-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Congenital Obstructive Megaureter

Keywords

Congenital obstructive megaureter, Urinary malformation, Ureterovesical junction, Hydronephrosis, Renal dysplasia

Brief summary

Congenital obstructive megaureter is a urinary malformation affecting the ureterovesical junction and causing obstruction to the flow of urine. It is the second most common cause of hydronephrosis. This malformation affects four times more boys than girls and is bilateral in 25% of cases. It is also associated with contralateral renal dysplasia in 15% of cases. The obstruction is linked to aperistalsis and hypertrophy of the circular muscle bundles and increased collagen 1 level. This malformation is accessible to antenatal screening from the second trimester. It falls within the scope of CAKUT and requires regular monitoring. Indeed, this uropathy can cause repeated pyelonephritis, kidney scarring and affected kidney function.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Years to 17 Years

Healthy volunteers

Inclusion criteria

* Minor patient (from 1 to 17 years old) * Patient treated between January 2010 and December 2017 in one of the participating centers for an obstructive congenital mega-ureter * Subject (and/or his parental authority) not having expressed, after information, his opposition to the reuse of his data for the purposes of this research

Exclusion criteria

* Subject (and/or his parental authority) having expressed, after information, his opposition to the reuse of his data for the purposes of this research

Design outcomes

Primary

Measure	Time frame	Description
Determine over the past seven years, the operability factors of patients aged 0 to 5 years regardless of the surgical technique used	Files analysed retrospectively from January 01, 2010 to December 31, 2017 will be examined	This study aims to make a retrospective inventory and perspective on the management of congenital obstructive mega ureter

Countries

France

Outcome results