Neurodegenerative Disorders
Conditions
Brief summary
Color discrimination deficit is a common manifestation of Alzheimer's disease (AD). However, the pathophysiology of this dysfunction remains poorly understood. The aim of the present study was to evaluate color discrimination using the Farnsworth-Munsell 100 hue test in patients with AD and mild cognitive impairment (MCI), compared with age-matched control subjects. As a secondary aim, we evaluated whether the outcomes of these visual tests were associated with cognitive.
Interventions
OTHERData collection
Neuropsychological assessment, FM-1OO, brain MRI, electroencephalogram and biomarker datas will be collected
Sponsors
Fujian Medical University Union Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* All patients underwent extensive clinical examination including thorough neurological and somatic examination by a specialized neurologist or geriatrician and extensive neuropsychological examination by a trained psychologist. AD was diagnosed according to the NINCDS-ADRDA criteria.
Exclusion criteria
* We excluded individuals with noncompensated somatic illnesses, a history of a psychiatric disorder, color blindness, ophthalmological pathology, severe cranial trauma, focal neurological signs or magnetic resonance imaging examinations suggestive of cerebrovascular disturbances.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MoCA scores | Baseline | The Montreal Cognitive Assessment (MoCA) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ACE-III scores | Baseline | Addenbrooke's Cognitive Examination (ACE) score |
Other
| Measure | Time frame | Description |
|---|---|---|
| TES | Baseline | The total error score |
Countries
China
Contacts
Primary ContactXiaodong Pan, Doctor
Outcome results
None listed