Study on Prenatal Diagnosis and Closed-loop Management System of Congenital Talipes Equinovarus

Congenital Talipes Equinovarus Prenatal Diagnosis and Closed Loop Management System Single Center Observational Prospective Study Clinical Study Protocol

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05638490

Enrollment

100

Registered

2022-12-06

Start date

2022-08-03

Completion date

2025-12-31

Last updated

2022-12-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prenatal Diagnosis and Closed-loop Management System of Congenital Talipes Equinovarus

Brief summary

The study intends to establish a closed-loop management from prenatal to postnatal through prospective cohort, and comprehensively utilize ultrasound and MRI technology to establish a prenatal diagnosis and evaluation system for congenital talipes equinovarus. On the basis of existing genetic testing, further use of whole-exome sequencing and other genomic methods to explore possible pathogenic genes and loci, and clarify the pathogenic mechanism of congenital talipes equinovarus. Therefore, congenital talipes equinovarus can improve its diagnosis and treatment capacity, reduce the disability rate related to congenital talipes equinovarus, and prevent it well.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

1）Single pregnant women 2) congenital talipes equinovarus suggested by ultrasound

Exclusion criteria

Twin or multiple pregnancies

Design outcomes

Primary

Measure	Time frame	Description
Genetic testing results of congenital talipes equinovarus	2 years	chromosomal microarray analysis or whole exome screening to find genetic abnormalities of congenital talipes equinovarus

Countries

China

Outcome results