Heart Failure, Diastolic, Heart Failure, Preserved Ejection Fraction
Conditions
Keywords
left atrial reservoir strain, HFA-PEFF, LA strain, Heart failure with preserved ejection fraction (HFpEF)
Brief summary
The goal of this observational study is to learn about left atrial reservoir strain in patients with heart failure with preserved ejection fraction. The main questions it aims to answer are: * Usefullness of LARS as a predictor of high HFA-PEFF diagnostic algorithm scores (≥5) * The relative importance of LARS in variables including each component of HFA-PEFF and traditional cardiovascular risk factors.
Interventions
DIAGNOSTIC_TESTLeft atrial reservoir strain
LA strain measurements can be obtained by two dimensional (2D) speckle tracking echocardiography (STE). Longitudinal strain and strain rate curves are generated for each of six atrial segments, obtained from the apical four and two chamber views. In the reservoir phase, as the LA fills and stretches, there is positive atrial strain that reaches its peak in systole at the end of LA filling, prior to opening of the mitral valve. Following this, passive LA emptying ensues with opening of the mitral valve resulting in decreased atrial strain with negative deflection of the strain curve up to a plateau period which is analogous to diastasis. LA reservoir strain (LARS), or peak atrial longitudinal strain or LA systolic strain, is measured at the end of the reservoir phase.
Sponsors
Yonsei University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Participants with ICD-10 code of heart failure (I50) from August 2021 to July 2022 * 20-year-old or higher age * Participants who are available to measure left atrial reservoir strain
Exclusion criteria
* Left ventricular ejection fraction \<50% * Supraventricular arrhythmia (e.g. atrial flutter/fibrillation, atrial tachycardia) * Participants who are given pacemaker or ICD implantation procedure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Statistical significant of LA reservoir strain to estimate high HFA-PEFF score (≥5) | through study completion, an average of 1 year | Statistical significant of LA reservoir strain to estimate high HFA-PEFF score (≥5) in multiple linear regression analysis. |
| Relative importance of left atrial reservoir strain | through study completion, an average of 1 year | Relative importance of left atrial reservoir strain among variables, including component of HFA-PEFF score, using supervised machine learning algorithm (random forest analysis) to estimate high HFA-PEFF score (≥5). LA reserver strain was measured using Automated Functional Imaging (AFI) of the left atrium 3.0 version (GE Healthcare) |
Countries
South Korea
Contacts
Primary ContactMinkwan Kim
Outcome results
None listed