Periodontal Diseases
Conditions
Brief summary
Previous studied have investigated the pathophysiological role and expression of Cathepsin K (Ctsk) , receptor activator of the NF-κB ligand (RANKL) and periostin in active periodontitis and peri-implantitis lesions. However, the potential influence of non-surgical periodontal therapy including scaling and root planning on the bone remodeling markers level over different trial times have not well determined. Thus, the current research is conducted to address this influence. Thus, the research question will be: In patients with periodontitis, does the level of bone remodeling markers altered after successful NSPT during different healing time periods?
Interventions
PROCEDURERoot surface debridement
subjects will be examined for clinical periodontal parameters, their saliva samples will be collected, and then receiving full scaling using ultrasonic device, and oral hygiene instructions and motivation. After one week, the same clinical parameters, saliva sampling will be taken, and received full root surface debridement (RSD) using curette hand instruments (Gracey, USA) (First visit). One month and three months after first visit, the same clinical measurements, saliva will characterize as second and third visits, respectively.
Sponsors
University of Baghdad
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
1. Both males and females. 2. Unstable periodontitis. 3. No previous periodontal treatment is conducted during the past 6 months. 4. Good general health without history of any systemic diseases. 5. Present with at least 20 teeth. 6. Non-smokers.
Exclusion criteria
1. Subjects have any intraoral plaque retentive factors such as those wearing partial denture, crown and bridges, and orthodontic appliances. 2. Subjects receiving antibiotic therapy during the previous 3 months. 3. Pregnant or lactating women. 4. Smokers. 5. Not willing to participate or continue to conduct the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bone remodeling markers including salivary RANKL | At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit | To investigate the alterations in the level of salivary RANKL pg/ml following Non-surgical periodontal therapy in unstable periodontitis patients during different healing time periods. |
| Bone remodeling markers including salivary Cathepsin k | At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit | To investigate the alterations in the level of salivary Cathepsin k pg/ml following Non-surgical periodontal therapy in unstable periodontitis patients during different healing time periods. |
| Bone remodeling markers including salivary periostin | At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit | To investigate the alterations in the level of salivary periostin pg/ml following Non-surgical periodontal therapy in unstable periodontitis patients during different healing time periods. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical periodontal parameters including Bleeding on probing | At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit | To measure Clinical periodontal parameters including Bleeding on probing following Non-surgical periodontal therapy in unstable periodontitis patients during different healing time periods. |
| Clinical periodontal parameters including probing pocket depth | At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit | To measure Clinical periodontal parameters including probing pocket depth following Non-surgical periodontal therapy in unstable periodontitis patients during different healing time periods. |
| Clinical periodontal parameters including clinical attachment loss | At a base line visit (Zero time visit), After one week (first visit), and One month and three months after first visit | To measure Clinical periodontal parameters including clinical attachment loss following Non-surgical periodontal therapy in unstable periodontitis patients during different healing time periods. |
Countries
Iraq
Outcome results
None listed